Journal article
Endoglin (CD105) and vascular endothelial growth factor as prognostic markers in prostatic adenocarcinoma
American journal of clinical pathology, v 127(4), pp 572-579
01 Apr 2007
PMID: 17369132
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We studied endoglin and vascular endothelial growth factor (VEGF) expression as prognostic markers in prostatic adenocarcinoma in 50 radical prostatectomy specimens. Cases were further categorized by Gleason score as follows: 8 to 10, 9 cases; 7 (4 + 3), 9 cases; 7 (3 + 4), 14 cases; 6, 13 cases; and 4 or 5, 5 cases. All cases were immunostained for endoglin, CD31, and VEGF Positively stained microvessels were counted in densely vascular foci in a x 400 field. VEGF staining intensity was scored on a 2-tiered scale. Results were correlated with survival and other parameters. Endoglin demonstrated significantly more microvessels than did CD31 (mean +/- SD, 37 +/- 15 vs 22 +/- 17; P < .001). VEGF expression was low in 21 cases (42%) and high in 29 (58%). Endoglin correlated positively with Gleason score, lymph node metastases, tumor stage, and preoperative prostate-specific antigen level (P < .05) but not with CD31. VEGF correlated significantly with angiolymphatic invasion and Gleason score (P < .05). A high endoglin microvessel count and VEGF expression correlated with shorter survival. Endoglin is a more specific and sensitive marker for tumor angiogenesis than CD31 and may serve as a prognostic marker for prostatic adenocarcinoma.
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Details
- Title
- Endoglin (CD105) and vascular endothelial growth factor as prognostic markers in prostatic adenocarcinoma
- Creators
- Yasser M. El-Gohary - Allegheny General HospitalJan F. Silverman - Allegheny General HospitalPeter R. Olson - Allegheny General HospitalYulin L. Liu - Allegheny General HospitalJeffrey K. Cohen - Allegheny General HospitalRalph Miller - Allegheny General HospitalReda S. Saad - Allegheny General Hospital
- Publication Details
- American journal of clinical pathology, v 127(4), pp 572-579
- Publisher
- Oxford Univ Press
- Number of pages
- 8
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pathology (and Laboratory Medicine)
- Web of Science ID
- WOS:000245248100009
- Scopus ID
- 2-s2.0-34247104610
- Other Identifier
- 991019168903204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Pathology