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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Endothelin and the neurovascular unit in pediatric traumatic brain injury
Neurological research (New York), v 33(2), pp 127-132
Mar 2011
PMID: 21801587
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This study characterized the association between endothelin-1, cerebral hemodynamics, and histopathology after fluid percussion brain injury in the newborn pig.
Lateral fluid percussion injury was induced in newborn pigs equipped with a closed cranial window. Cerebral blood flow was determined with radiolabeled microspheres and cerebrospinal fluid endothelin-1 was measured by radioimmunoassay.
Cerebrospinal fluid endothelin-1 was increased from 26±4 to 296±37 pg/ml (∼10(-10) M) at 8 hours following fluid percussion injury. Post-injury treatment (30 minutes) with the endothelin-1 antagonist BQ-123 (1 mg/kg, intravenous) blocked pial artery vasoconstriction to topical endothelin-1 (∼10(-10) M) and blunted fluid percussion injury-induced reductions in cerebral blood flow at 8 hours post-insult (56±6 and 26±4 ml/minute versus 57±6 and 40± ml/minute; 100 g for cerebral blood flow before injury and 8 hours post-fluid percussion injury in vehicle and BQ-123 post-treated animals, respectively). Fluid percussion injury resulted in neuronal cell loss and decreased microtubule associated protein 2 immunoreactivity in the parietal cortex, which were blunted by BQ-123.
These data indicate that fluid percussion injury-induced changes in cerebral hemodynamics are associated with neuronal damage and that endothelin-1 contributes to fluid percussion injury-induced histopathologic changes.
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Details
- Title
- Endothelin and the neurovascular unit in pediatric traumatic brain injury
- Creators
- William M Armstead - University of PennsylvaniaRamesh Raghupathi - University of Pennsylvania
- Publication Details
- Neurological research (New York), v 33(2), pp 127-132
- Grant note
- R01 HD057355 / NICHD NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000287516600003
- Scopus ID
- 2-s2.0-79951901005
- Other Identifier
- 991019168007204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology
- Neurosciences