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Endotracheal naloxone reversal of morphine-induced respiratory depression in rabbits
Journal article   Peer reviewed

Endotracheal naloxone reversal of morphine-induced respiratory depression in rabbits

Michael I. Greenberg, James R. Roberts and Steven I. Baskin
Annals of emergency medicine, v 9(6), pp 289-292
1980
DOI: https://doi.org/10.1016/S0196-0644(80)80060-6
PMID: 7386953
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

animal studies naloxone respiratory depression treatment for respiratory depression treatment with endotracheal naloxone
In an emergency, intravenous access may be difficult to obtain rapidly. Alternate routes of administration for drugs are, therefore, desirable. Our study was performed to determine if naloxone could be efficacious in reversing morphine-induced respiratory depression in rabbits when administered using the endotracheal route. Our results indicate that naloxone administered in this fashion is effective in reversing morphine-induced respiratory depression in the rabbit. Mean minute ventilation was depressed to greater than half of resting baseline levels using morphine sulfate. Endotracheally administered naloxone reversed this respiratory depression and resulted in a greater than five-fold increase in mean minute ventilation above baseline levels. We concluded that endotracheal naloxone is efficacious in reversing morphine-induced respiratory depression in the rabbit. The endotracheal route may be an effective alternative for naloxone administration in man when rapid intravenous access is not obtainable.

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27 citations in Web of Science
52 citations in Scopus

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Web of Science research areas
Emergency Medicine
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