Journal article
Endovascular therapy of wake-up strokes in the modern era of stent retriever thrombectomy
Journal of neurointerventional surgery, v 8(3), pp 240-243
01 Mar 2016
PMID: 25634902
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background Endovascular treatment of wake-up strokes (WUS) has been previously described, mostly with the use of pharmacological thrombolysis or first generation thrombectomy devices.
Objective To describe outcomes of WUS treated with modern endovascular therapy since the Food and Drug Administration approval of stent retrievers, and to identify predictors of good clinical outcome in this population of stroke patients.
Methods We performed a multicenter retrospective analysis of consecutive patients with WUS who underwent thrombectomy with stent retrievers Trevo (Stryker, Kalamazoo, Michigan, USA) and Solitaire FR (Covidien, Irvine, California, USA), or primary aspiration thrombectomy. We correlated favorable clinical outcomes with demographic, clinical, and technical characteristics.
Results 52 patients were included in this study; 46 (88%) cases were treated with stent retrievers and 6 (12%) were treated with primary aspiration thrombectomy alone. Successful recanalization (Thrombolysis in Cerebral Infarction (TICI) 2b/3) was achieved in 36 (69%) patients. Favorable clinical outcome at 3 months, defined as a modified Rankin Scale score of 0-2, was achieved in 25 (48%) patients. Duration of intervention <30min and its success, defined as TICI 2b/3 recanalization, were strong predictors of favorable clinical outcome at 90 days (p<0.001 and p<0.0001, respectively).
Conclusions Our study indicates that endovascular treatment of WUS with stent retrievers and aspiration thrombectomy is safe and effective.
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Details
- Title
- Endovascular therapy of wake-up strokes in the modern era of stent retriever thrombectomy
- Creators
- Maxim Mokin - University of South FloridaPeter Kan - University of South FloridaSananthan Sivakanthan - University of South FloridaErol Veznedaroglu - Capital HealthMandy J. Binning - Capital HealthKenneth M. Liebman - Capital HealthPinakin R. Jethwa - Capital HealthRaymond D. Turner - Medical University of South CarolinaAquilla S. Turk - Medical University of South CarolinaSabareesh K. Natarajan - University at Buffalo, State University of New YorkAdnan H. Siddiqui - University at Buffalo, State University of New YorkElad I. Levy - University at Buffalo, State University of New York
- Publication Details
- Journal of neurointerventional surgery, v 8(3), pp 240-243
- Publisher
- Bmj Publishing Group
- Number of pages
- 4
- Grant note
- R01NS064592 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) NINDS 1R01NS064592-01A1; NIBIB 5 RO1 EB002873-07 / National Institutes of Health, University at Buffalo; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Toshiba Abbott; Abbott Laboratories R01EB002873 / NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Biomedical Imaging & Bioengineering (NIBIB)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurology; Neurosurgery
- Web of Science ID
- WOS:000371327000009
- Scopus ID
- 2-s2.0-84958601409
- Other Identifier
- 991021918102504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neuroimaging
- Surgery