Journal article
Energetic adaptations persist after bariatric surgery in severely obese adolescents
Obesity (Silver Spring, Md.), v 23(3), pp 591-601
Mar 2015
PMID: 25707380
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective
Energetic adaptations induced by bariatric surgery have not been studied in adolescents or for extended periods postsurgery. Energetic, metabolic, and neuroendocrine responses to Roux‐en‐Y gastric bypass (RYGB) surgery were investigated in extremely obese adolescents.
Methods
At baseline and at 1.5, 6, and 12 months post‐baseline, 24‐h room calorimetry, body composition, and fasting blood biochemistries were measured in 11 obese adolescents relative to five matched controls.
Results
In the RYGB group, mean weight loss was 44 ± 19 kg at 12 months. Total energy expenditure (TEE), activity EE, basal metabolic rate (BMR), sleep EE, and walking EE significantly declined by 1.5 months (P = 0.001) and remained suppressed at 6 and 12 months. Adjusted for age, sex, fat‐free mass, and fat mass, EE was still lower than baseline (P = 0.001). Decreases in serum insulin, leptin, and triiodothyronine (T3), gut hormones, and urinary norepinephrine (NE) paralleled the decline in EE. Adjusted changes in TEE, BMR, and/or sleep EE were associated with decreases in insulin, homeostatic model assessment, leptin, thyroid stimulating hormone, total T3, peptide YY3‐36, glucagon‐like peptide‐2, and urinary NE and epinephrine (P = 0.001‐0.05).
Conclusions
Energetic adaptations in response to RYGB‐induced weight loss are associated with changes in insulin, adipokines, thyroid hormones, gut hormones, and sympathetic nervous system activity and persists 12 months postsurgery.
Metrics
Details
- Title
- Energetic adaptations persist after bariatric surgery in severely obese adolescents
- Creators
- Nancy F Butte - Baylor College of MedicineMary L Brandt - Baylor College of MedicineWilliam W Wong - Baylor College of MedicineYan Liu - Baylor College of MedicineNitesh R Mehta - Baylor College of MedicineTheresa A Wilson - Baylor College of MedicineAnne L Adolph - Baylor College of MedicineMaurice R Puyau - Baylor College of MedicineFiroz A Vohra - Baylor College of MedicineRoman J Shypailo - Baylor College of MedicineIssa F Zakeri - Drexel University
- Publication Details
- Obesity (Silver Spring, Md.), v 23(3), pp 591-601
- Publisher
- Wiley
- Number of pages
- 11
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000350249700014
- Scopus ID
- 2-s2.0-84925103829
- Other Identifier
- 991014878213404721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Endocrinology & Metabolism
- Nutrition & Dietetics