Journal article
Engineering Human Microbiota: Influencing Cellular and Community Dynamics for Therapeutic Applications
International review of cell and molecular biology, v 324
2016
PMID: 27017007
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The complex relationship between microbiota, human physiology, and environmental perturbations has become a major research focus, particularly with the arrival of culture-free and high-throughput approaches for studying the microbiome. Early enthusiasm has come from results that are largely correlative, but the correlative phase of microbiome research has assisted in defining the key questions of how these microbiota interact with their host. An emerging repertoire for engineering the microbiome places current research on a more experimentally grounded footing. We present a detailed look at the interplay between microbiota and host and how these interactions can be exploited. A particular emphasis is placed on unstable microbial communities, or dysbiosis, and strategies to reestablish stability in these microbial ecosystems. These include manipulation of intermicrobial communication, development of designer probiotics, fecal microbiota transplantation, and synthetic biology.
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Details
- Title
- Engineering Human Microbiota: Influencing Cellular and Community Dynamics for Therapeutic Applications
- Creators
- S Woloszynek - Drexel UniversityS Pastor - Drexel UniversityJ C Mell - Drexel UniversityN Nandi - Drexel UniversityB Sokhansanj - ThiokolG L Rosen - Drexel University
- Publication Details
- International review of cell and molecular biology, v 324
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology; Electrical and Computer Engineering
- Web of Science ID
- WOS:000377028800003
- Scopus ID
- 2-s2.0-84959897730
- Other Identifier
- 0128052236; 9780128052235; 991019168815904721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Cell Biology