Journal article
Engineering Protein Delivery Depots for Cancer Immunotherapy
Bioconjugate chemistry, v 30(3), pp 515-524
01 Mar 2019
PMID: 30839198
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Cancer immunotherapy that induces a tumor-specific immune response for cancer eradication has received tremendous attention. To enhance the immunotherapeutic effects, many drug delivery strategies have been developed to overcome the physiological barriers as well as to reduce toxicity. For example, intratumoral or peritumoral administration of injectable depot formulations can directly target tumor sites for immunotherapy. Compared with systemic administration of therapeutics, this strategy has minimal side effects. Such local treatment can also trigger a systemic immune response for inhibiting tumor metastasis. This Topical Review highlights the recent studies on depot-mediated delivery of protein/peptide therapeutics for cancer immunotherapy. Further opportunities and challenges in this field are also discussed.
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Details
- Title
- Engineering Protein Delivery Depots for Cancer Immunotherapy
- Creators
- Di Wen - University of California, Los AngelesGuojun Chen - University of California, Los AngelesQian Chen - University of California, Los AngelesPeter Y. Li - Drexel University, Materials Science and EngineeringHao Cheng - Drexel UniversityZhen Gu - University of California, Los Angeles
- Publication Details
- Bioconjugate chemistry, v 30(3), pp 515-524
- Publisher
- American Chemical Society; Washington, DC
- Number of pages
- 10
- Grant note
- R21AI133372 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) Jonsson Comprehensive Cancer Center at UCLA R21AI133372 / National Institute of Allergy And Infectious Diseases of the National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Materials Science and Engineering
- Web of Science ID
- WOS:000462260300003
- Scopus ID
- 2-s2.0-85062797477
- Other Identifier
- 991019168900804721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemical Research Methods
- Biochemistry & Molecular Biology
- Chemistry, Multidisciplinary
- Chemistry, Organic