Journal article
Engineering long-circulating nanomaterial delivery systems
Current opinion in biotechnology, v 66, pp 131-139
Dec 2020
PMID: 32795661
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
One of the grand challenges at the forefront of bionanomaterials is their quick clearance in blood circulation. Progress has been made in understanding nanomaterial-biological system interactions and in developing new strategies to extend the blood circulation time of nanomaterials. Here, we first review interactions between the complement system and nanomaterials as well as clearance pathways in major organs such as the liver, spleen, and kidneys. We then discuss new approaches to prolong the blood circulation of nanomaterials with a focus on grafting polymers and biomimetic camouflages including cell membrane coating and hybrid vesicles. In the end, we provide insights into the pros and cons of these approaches and our perspectives for advancing this field.
Metrics
Details
- Title
- Engineering long-circulating nanomaterial delivery systems
- Creators
- Zhiyuan Fan - Drexel UniversityPu Zhu - Drexel UniversityYucheng Zhu - Drexel UniversityKevin Wu - Drexel UniversityChristopher Y Li - Drexel UniversityHao Cheng - Drexel University
- Publication Details
- Current opinion in biotechnology, v 66, pp 131-139
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Materials Science and Engineering
- Web of Science ID
- WOS:000601001000017
- Scopus ID
- 2-s2.0-85089270866
- Other Identifier
- 991019169793304721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemical Research Methods
- Biotechnology & Applied Microbiology