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Journal article
Engineering of Corneal Tissue through an Aligned PVA/Collagen Composite Nanofibrous Electrospun Scaffold
Nanomaterials (Basel, Switzerland), Vol.8(2), p124
24 Feb 2018
PMCID: PMC5853755
PMID: 29495264
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Corneal diseases are the main reason of vision loss globally. Constructing a corneal equivalent which has a similar strength and transparency with the native cornea, seems to be a feasible way to solve the shortage of donated cornea. Electrospun collagen scaffolds are often fabricated and used as a tissue-engineered cornea, but the main drawback of poor mechanical properties make it unable to meet the requirement for surgery suture, which limits its clinical applications to a large extent. Aligned polyvinyl acetate (PVA)/collagen (PVA-COL) scaffolds were electrospun by mixing collagen and PVA to reinforce the mechanical strength of the collagen electrospun scaffold. Human keratocytes (HKs) and human corneal epithelial cells (HCECs) inoculated on aligned and random PVA-COL electrospun scaffolds adhered and proliferated well, and the aligned nanofibers induced orderly HK growth, indicating that the designed PVA-COL composite nanofibrous electrospun scaffold is suitable for application in tissue-engineered cornea.
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Details
- Title
- Engineering of Corneal Tissue through an Aligned PVA/Collagen Composite Nanofibrous Electrospun Scaffold
- Creators
- Zhengjie Wu - Tsinghua–Berkeley Shenzhen InstituteBin Kong - Tsinghua–Berkeley Shenzhen InstituteRui Liu - Tsinghua UniversityWei Sun - Tsinghua–Berkeley Shenzhen InstituteShengli Mi - Tsinghua University
- Publication Details
- Nanomaterials (Basel, Switzerland), Vol.8(2), p124
- Publisher
- MDPI
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Mechanical Engineering and Mechanics
- Identifiers
- 991019167693804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Chemistry, Multidisciplinary
- Materials Science, Multidisciplinary
- Nanoscience & Nanotechnology
- Physics, Applied