Journal article
Engineering the extracellular matrix for clinical applications: Endoderm, mesoderm, and ectoderm
Biotechnology journal, v 9(3), pp 337-347
Mar 2014
PMID: 24390851
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Tissue engineering is rapidly progressing from a research-based discipline to clinical applications. Emerging technologies could be utilized to develop therapeutics for a wide range of diseases, but many are contingent on a cell scaffold that can produce proper tissue ultrastructure. The extracellular matrix, which a cell scaffold simulates, is not merely a foundation for tissue growth but a dynamic participant in cellular crosstalk and organ homeostasis. Cells change their growth rates, recruitment, and differentiation in response to the composition, modulus, and patterning of the substrate on which they reside. Cell scaffolds can regulate these factors through precision design, functionalization, and application. The ideal therapy would utilize highly specialized cell scaffolds to best mimic the tissue of interest. This paper discusses advantages and challenges of optimized cell scaffold design in the endoderm, mesoderm, and ectoderm for clinical applications in tracheal transplant, cardiac regeneration, and skin grafts, respectively.
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Details
- Title
- Engineering the extracellular matrix for clinical applications: Endoderm, mesoderm, and ectoderm
- Creators
- Miguel L. Williams - Harvard UniversitySujata K. Bhatia - Harvard University
- Publication Details
- Biotechnology journal, v 9(3), pp 337-347
- Publisher
- Wiley
- Number of pages
- 11
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000332339100004
- Scopus ID
- 2-s2.0-84897607842
- Other Identifier
- 991021229995104721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemical Research Methods
- Biotechnology & Applied Microbiology