Journal article
Enhanced Elastin and Fibrillin Gene Expression in Chronically Photodamaged Skin
Journal of investigative dermatology, v 103(2), pp 182-186
Aug 1994
PMID: 8040608
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Cutaneous aging consists of chronologic aging as well as actinic damage, referred to as photoaging. Most of the morphologic changes associated with an aged appearance result from actinic damage to the skin. The morphologic changes in sun-damaged skin are associated with accumulation of material having the staining characteristics of elastin, known as solar elastosis, in the superficial dermis. Previous studies have demonstrated the presence of elastin within areas of solar elastosis; however, little is known about the mechanisms leading to elastin accumulation in photoaged skin. In addition, fibrillin, the fibrillar component of elastic fibers, has been found in small amounts in solar elastosis. In this study we demonstrate increased elastin mRNA levels in photoaged skin, as well as increased elastin and fibrillin mRNAs in skin explant-derived fibroblasts using Northern hybridizations, compared with controls from sun-protected sites of the same individual. Increased elastin mRNA levels result from transcriptional upregulation of the gene, as demonstrated by transient transfections with a human elastin promoter/chloramphenicol acetyltransferase construct. Elevated mRNA levels were also correlated with increased elastin and fibrillin deposition in paired biopsy specimens from photodamaged and non-sun-exposed skin, as demonstrated by immunohistochemical staining. Thus, approaches to counteract transcriptional activation of elastin gene expression may be useful in preventing the changes associated with cutaneous photoaging.
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Details
- Title
- Enhanced Elastin and Fibrillin Gene Expression in Chronically Photodamaged Skin
- Creators
- Yue Qiu Chen - Jefferson InstituteEric F Bernstein - Jefferson CollegeKatsuto Tamai - Jefferson InstituteKenneth J Shepley - Jefferson InstituteKenneth S Resnik - Jefferson InstituteH.u.i. Zhang - Brookdale Center for Molecular Biology, Mt. Sinai School of Medicine, New York, New York, U.S.ARocky Tuan - Jefferson InstituteAlain Mauviel - Jefferson InstituteJouni Uitto - Jefferson InstituteHua Zhang - Electrical and Computer Engineering
- Publication Details
- Journal of investigative dermatology, v 103(2), pp 182-186
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Electrical and Computer Engineering
- Web of Science ID
- WOS:A1994NZ38900010
- Scopus ID
- 2-s2.0-0027965284
- Other Identifier
- 991019184314904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Dermatology