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Journal article
Enhanced Therapeutic Anti-Inflammatory Effect of Betamethasone on Topical Administration with Low-Frequency, Low-Intensity (20 kHz, 100 mW/cm2) Ultrasound Exposure on Carrageenan-Induced Arthritis in a Mouse Model
Ultrasound in medicine & biology, v 41(9), pp 2449-2457
Sep 2015
PMID: 26003010
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The purpose of this work was to investigate whether low-frequency, low-intensity (20 kHz, <100 mW/cm2, spatial-peak, temporal-peak intensity) ultrasound, delivered with a lightweight (<100 g), tether-free, fully wearable, battery-powered applicator, is capable of reducing inflammation in a mouse model of rheumatoid arthritis. The therapeutic, acute, anti-inflammatory effect was estimated from the relative swelling induced in mice hindlimb paws. In an independent, indirect approach, the inflammation was bio-imaged by measuring glycolytic activity with near-infrared labeled 2-deoxyglucose. The outcome of the experiments indicated that the combination of ultrasound exposure and topical application of 0.1% (w/w) betamethasone gel resulted in statistically significantly (p < 0.05) enhanced anti-inflammatory activity in comparison with drug or ultrasound treatment alone. The present study underscores the potential benefits of low-frequency, low-intensity ultrasound-assisted drug delivery. However, the proof of concept presented indicates the need for additional experiments to systematically evaluate and optimize the potential of, and the conditions for, tolerable low-frequency, low-intensity ultrasound-promoted non-invasive drug delivery.
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Details
- Title
- Enhanced Therapeutic Anti-Inflammatory Effect of Betamethasone on Topical Administration with Low-Frequency, Low-Intensity (20 kHz, 100 mW/cm2) Ultrasound Exposure on Carrageenan-Induced Arthritis in a Mouse Model
- Creators
- Gadi Cohen - Hebrew University of JerusalemHiba Natsheh - Hebrew University of JerusalemYouhan Sunny - Drexel UniversityChristopher R. Bawiec - Drexel UniversityElka Touitou - Hebrew University of JerusalemMelissa A. Lerman - Children's Hospital of PhiladelphiaPhilip Lazarovici - Hebrew University of JerusalemPeter A. Lewin - Drexel University
- Publication Details
- Ultrasound in medicine & biology, v 41(9), pp 2449-2457
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000363923400020
- Scopus ID
- 2-s2.0-84938199600
- Other Identifier
- 991019167622504721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Acoustics
- Radiology, Nuclear Medicine & Medical Imaging