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Enhancement of Hypoxemia by Atrial Shunting in Cystic Fibrosis
Journal article   Peer reviewed

Enhancement of Hypoxemia by Atrial Shunting in Cystic Fibrosis

Alexander Davidson, Krishnaswany Chandrasekaran, Louis Guida and Douglas S. Holsclaw
Chest, v 98(3), pp 543-545
Sep 1990
PMID: 2394134

Abstract

Patients with CF may develop hypoxemia which seems disproportionate to the degree of pulmonary disease. In a series of patients with CF and advanced pulmonary disease undergoing transesophageal echocardiography for the evaluation of cor pulmonale, eight of 15 patients were found to have atrial shunts through a stretched foramen ovale. To our knowledge, this is the first observation of intracardiac shunting in CF. This phenomenon may account for unexplained levels of cyanosis and worsening of hypoxemia with exercise, vasodilators, or PEEP and poses the threat of paradoxic emboli when central venous lines are used in these patients.

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Web of Science research areas
Critical Care Medicine
Respiratory System
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