Journal article
Enhancing neural activity to drive respiratory plasticity following cervical spinal cord injury
Experimental neurology, v 287(Pt 2), pp 276-287
01 Jan 2017
PMID: 27582085
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Cervical spinal cord injury (SCI) results in permanent life-altering sensorimotor deficits, among which impaired breathing is one of the most devastating and life-threatening. While clinical and experimental research has revealed that some spontaneous respiratory improvement (functional plasticity) can occur post-SCI, the extent of the recovery is limited and significant deficits persist. Thus, increasing effort is being made to develop therapies that harness and enhance this neuroplastic potential to optimize long-term recovery of breathing in injured individuals. One strategy with demonstrated therapeutic potential is the use of treatments that increase neural and muscular activity (e.g. locomotor training, neural and muscular stimulation) and promote plasticity. With a focus on respiratory function post-SCI, this review will discuss advances in the use of neural interfacing strategies and activity-based treatments, and highlights some recent results from our own research. (C) 2016 Elsevier Inc All rights reserved.
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Details
- Title
- Enhancing neural activity to drive respiratory plasticity following cervical spinal cord injury
- Creators
- Kristiina M. Hormigo - Drexel UniversityLyandysha V. Zholudeva - Drexel UniversityVictoria M. Spruance - Drexel UniversityVitaliy Marchenko - Drexel UniversityMarie-Pascale Cote - Drexel UniversityStephane Vinit - Versailles Saint-Quentin-en-Yvelines UniversitySimon Giszter - Drexel UniversityTatiana Bezdudnaya - Drexel UniversityMichael A. Lane - Drexel University
- Publication Details
- Experimental neurology, v 287(Pt 2), pp 276-287
- Publisher
- Elsevier
- Number of pages
- 12
- Grant note
- R01NS081112 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) R01-NS081112 / NINDS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) SC140038 / United States Department of Defense (USAMRAH) National Institutes of Health (NIH); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Cure Paralysis Now Foundation 338432 / Craig. H. Neilsen Foundation
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy; Neurology
- Web of Science ID
- WOS:000391159100020
- Scopus ID
- 2-s2.0-84994525339
- Other Identifier
- 991019168569004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences