Journal article
Enhancing neural efficiency of cognitive processing speed via training and neurostimulation: An fNIRS and TMS study
NeuroImage (Orlando, Fla.), v 198, pp 73-82
Sep 2019
PMID: 31078636
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Speed of Processing (SoP) represents a fundamental limiting step in cognitive performance which may underlie General Intelligence. The measure of SoP is particularly sensitive to aging, neurological or cognitive diseases, and has become a benchmark for diagnosis, cognitive remediation, and enhancement. Neural efficiency of the Dorsolateral Prefrontal Cortex (DLPFC) is proposed to account for individual differences in SoP. However, the mechanisms by which DLPFC efficiency is shaped by training and whether it can be enhanced remain elusive. To address this, we monitored the brain activity of sixteen healthy participants using functional Near Infrared Spectroscopy (fNIRS) while practicing a common SoP task (Symbol Digit Substitution Task) across 4 sessions. Furthermore, in each session, participants received counterbalanced excitatory repetitive transcranial magnetic stimulation (rTMS) during mid-session breaks. Results indicate a significant involvement of the left-DLPFC in SoP, whose neural efficiency is consistently increased through task practice. Active neurostimulation, but not Sham, significantly enhanced the neural efficiency. These findings suggest a common mechanism by which neurostimulation may aid to accelerate learning.
•Left-DLPFC activity is associated with Symbol-Digit Performance.•Practice of SDST increases neural efficiency.•Excitatory rTMS to left-DLPFC further increases neural efficiency.•Neuroimaging may help evaluate the effects of neurostimulation paradigms.
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Details
- Title
- Enhancing neural efficiency of cognitive processing speed via training and neurostimulation: An fNIRS and TMS study
- Creators
- Adrian Curtin - Shanghai Jiao Tong UniversityHasan Ayaz - Children's Hospital of PhiladelphiaYingying Tang - Shanghai Mental Health CenterJunfeng Sun - Shanghai Jiao Tong UniversityJijun Wang - Shanghai Mental Health Center, Shanghai Jiao Tong University, School of Medicine, Shanghai, ChinaShanbao Tong - Shanghai Jiao Tong University
- Publication Details
- NeuroImage (Orlando, Fla.), v 198, pp 73-82
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000472495100007
- Scopus ID
- 2-s2.0-85065821361
- Other Identifier
- 991019168773504721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neuroimaging
- Neurosciences
- Radiology, Nuclear Medicine & Medical Imaging