Journal article
Environmental lighting alters the infection process in an animal model of AIDS
Pharmacology, biochemistry and behavior, v 51(4), pp 947-952
1995
PMID: 7675882
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In this study, we examined the effects of altered environmental lighting on the infection process of a murine leukemia virus, E-55(+), which induces a thymic lymphoma/leukemia in 100% of BALB.K mice inoculated as adults. One to two weeks after inoculation, high levels of proviral DNA are usually found. This is followed by an asymptomatic period of many weeks during which proviral DNA becomes essentially undetectable. Leukemia develops approximately 28 weeks postinoculation. In this experiment, one group of mice was exposed a consistent 10L : 14D cycle while a second was maintained in constant light (LL). A third group was exposed to a rotating cycle characterized by phase shifting a 10L : 14D cycle every three 24-h days (rLD). All cycles began 2 weeks prior to inoculation and were maintained thereafter. Animals were sacrificed at 1, 5, 10, and 15 weeks, and hematopoietic tissue was examined for proviral DNA content. At 1 week, LL- and rLD-exposed animals showed considerably less proviral DNA in bone marrow and spleen compared with controls. At 15 weeks, thymuses from controls were showing signs of infection whereas tissue from LL and rLD mice remained at background levels. We conclude that environmental lighting does alter the infective pattern displayed by this retrovirus, although whether this effect is mediated by changes in the target stem cells or through immunoenhancement has not yet been determined.
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Details
- Title
- Environmental lighting alters the infection process in an animal model of AIDS
- Creators
- D.L. McEachron - University of PennsylvaniaK.M. Tumas - University of PennsylvaniaK.J. Blank - Hahnemann University HospitalM.B. Prystowsky - University of Pennsylvania
- Publication Details
- Pharmacology, biochemistry and behavior, v 51(4), pp 947-952
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:A1995RF37700058
- Scopus ID
- 2-s2.0-0028981687
- Other Identifier
- 991019184056704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Behavioral Sciences
- Neurosciences
- Pharmacology & Pharmacy