Journal article
Environmentally-induced degradation of solid-lipid nanoparticles
Biointerface Research in Applied Chemistry, Vol.6(5), pp.1464-1468
15 Oct 2016
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Solid lipid nanoparticles (SLN) have been widely studied as drug and nutrient delivery vehicles. Due to their solid core, they are especially suited to oral delivery. In this paper, we examine-using Monte Carlo simulations-the effect of environmental agents such as enzymes on the degradation of SLNs. The process is dominated by surface erosion, since the solid nature of the core suppresses diffusion. As may be expected, smaller particles degrade more quickly than larger ones with a rate that is dominated by the surface area of the nanoparticle. As a result, particles with the same surface area degrade at approximately the same rate regardless of their asymmetry (length to width to height ratio). Quite surprisingly, the rate of reaction between the degradation agent and the lipids comprising the core does not significantly affect particle degradation. However, the rate of degradation is highly sensitive to the concentration of degradation agents in the surrounding solution.
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Details
- Title
- Environmentally-induced degradation of solid-lipid nanoparticles
- Creators
- Nily Dan - Drexel University
- Publication Details
- Biointerface Research in Applied Chemistry, Vol.6(5), pp.1464-1468
- Publisher
- Biointerface Research Applied Chemistry
- Number of pages
- 5
- Resource Type
- Journal article
- Language
- English
- Identifiers
- 991019312364004721
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- Web of Science research areas
- Chemistry, Applied