Journal article
Enzymatically activated microencapsulated liposomes can provide pulsatile drug release
The FASEB journal, v 4(8), pp 2533-2539
May 1990
PMID: 2110539
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
A system for the delayed or pulsed release of biologically active substances was achieved by encapsulating liposomes containing the substance of interest inside microcapsules. The microcapsules retain the liposomes but allow controlled diffusion of the active substance when it is released from the liposomes. Furthermore, by coating the liposomes with phospholipase A2 (an enzyme that removes an acyl group from the 2 position of phospholipids) before placing them within the microcapsule, a pulsatile release pattern was achieved both in vitro and in vivo. The time of onset of the pulse as well as the release rate can be controlled by the amount of phospholipase A2, the molecular weight of the poly(l‐lysine) that is used to coat the microencapsulated liposomes, and the composition of the phospholipid bilayer membrane. Even at 37°C the system would protect a model enzyme (horseradish peroxidase). When not placed inside the microencapsulated liposomes, the enzyme lost its activity in solution at 37°C in a few days, whereas it retained 40% of the initial activity after 30 days of incubation at 37°C inside the microencapsulated liposomes.—Kibat, P. G.; Igari, Y.; Wheatley, M. A.; Eisen, H. N.; Langer, R. Enzymatically activated microencapsulated liposomes can provide pulsatile drug release. FASEB J. 4: 2533‐2539; 1990.
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Details
- Title
- Enzymatically activated microencapsulated liposomes can provide pulsatile drug release
- Creators
- Paul G Kibat - Massachusetts Institute of TechnologyYasutaka Igari - Children's Hospital Medical CenterMargaret A Wheatley - Massachusetts Institute of TechnologyHerman N Eisen - Massachusetts Institute of TechnologyRobert Langer - Children's Hospital Medical Center
- Publication Details
- The FASEB journal, v 4(8), pp 2533-2539
- Publisher
- Wiley
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:A1990DE39300015
- Scopus ID
- 2-s2.0-0025361950
- Other Identifier
- 991014877904404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Biology
- Cell Biology