Journal article
Eosinophilic Esophagitis in Children
Paediatric drugs, v 17(3), pp 227-237
01 Jun 2015
PMID: 25792526
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Eosinophilic esophagitis (EoE) is a relatively common chronic immune-mediated disease of the esophagus characterized clinically by symptoms of esophageal dysfunction that vary by age. Histologically, EoE results in marked esophageal eosinophilia despite treatment with high-dose proton pump inhibition. The cornerstone of treatment is dietary restriction and/or pharmacologic therapy, mainly with topical steroids. This review briefly describes dietary therapy, but focuses on the various medical options in the treatment of EoE, with an emphasis on steroid-based therapy. Numerous landmark studies are reviewed describing the symptomatic and histologic endpoints as well as safety data. The literature strongly supports the use of topical steroid therapy as a means of significantly decreasing eosinophilic mucosal disease. Specifically, high-dose fluticasone propionate appears to be very effective, and has been shown to result in the resolution of mucosal eosinophilia in a large percentage of treated patients. Long-term studies over many years will need to determine whether mucosal healing will change the natural history of this stricture-causing disease. In addition to topical therapy, various other drug-based therapies are reported, including newer immune-based monoclonal antibodies.
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Details
- Title
- Eosinophilic Esophagitis in Children
- Creators
- Prerna Trivedy - Monmouth Medical CenterJonathan E. Teitelbaum - Monmouth Medical Center
- Publication Details
- Paediatric drugs, v 17(3), pp 227-237
- Publisher
- Springer Nature
- Number of pages
- 11
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000355702000006
- Scopus ID
- 2-s2.0-84953344776
- Other Identifier
- 991022007277604721
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Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Pediatrics
- Pharmacology & Pharmacy