Journal article
Eosinophilic esophagitis in children: Immunopathological analysis and response to fluticasone propionate
Gastroenterology (New York, N.Y. 1943), v 122(5), pp 1216-1225
May 2002
PMID: 11984507
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Eosinophilic esophagitis(EE) shares symptoms with gastroesophageal reflux disease but has distinctive pathologic features and unknown immunopathology. Treatments with antigen restriction or systemic immunosuppression pose problems with compliance and side effects. Topically applied steroids offer an attractive alternative treatment. The aims of this study were to determine the immunopathologic features of EE and the effectiveness of antigen-specific diet restriction (DR) and topical immunosuppression.
A prospective trial was conducted examining the impact of DR and swallowed fluticasone propionate (FP) on pediatric patients with EE. Clinicopathologic features, including immunohistochemical analysis of the esophageal mucosa, were measured before and after treatment.
Immunohistochemical analysis of 11 prospectively identified children showed a significantly greater number of mucosal CD3 and CD8 lymphocytes, as well as CD1a antigen-presenting cells compared with normal controls. DR did not induce clinical improvement in any patients, whereas all children who completed treatment with FP had resolution of symptoms. Posttreatment analysis of proximal and distal esophageal mucosa showed a significant reduction in the number of eosinophils, as well as CD3+ and CD8+ lymphocytes compared with pretreatment sections.
EE is characterized by immunologically active esophageal mucosa. FP. not DR. effectively relieves symptoms. FP significantly reduces mucosal inflammation associated with EE.
Metrics
Details
- Title
- Eosinophilic esophagitis in children: Immunopathological analysis and response to fluticasone propionate
- Creators
- Jonathan E. Teitelbaum - Harvard UniversityVictor L. Fox - Harvard Medical SchoolFrank J. Twarog - Harvard UniversitySamuel Nurko - Harvard Medical SchoolDon Antonioli - Harvard Medical SchoolGerald Gleich - University of UtahKamran Badizadegan - Harvard Medical SchoolGlenn T. Furuta - Harvard Medical School
- Publication Details
- Gastroenterology (New York, N.Y. 1943), v 122(5), pp 1216-1225
- Publisher
- Elsevier; PHILADELPHIA
- Number of pages
- 10
- Grant note
- NIDDK NIH HHS: K08 DK02564, P30 DK40561
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000175305500006
- Scopus ID
- 2-s2.0-0036234195
- Other Identifier
- 991022007383604721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Gastroenterology & Hepatology