Journal article
EphrinB3 is an anti-apoptotic ligand that inhibits the dependence receptor functions of EphA4 receptors during adult neurogenesis
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, v 1793(2)
01 Feb 2009
PMID: 18948148
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Eph receptors have been implicated in regulating a diverse array of cellular functions in the developing nervous system. Recently, Eph receptors have been shown to promote cell death in adult germinal zones; however, their mechanisms of action remain ill-defined. In this study, we demonstrate that EphA4 is a new member of the dependence receptors family. which can initiate cell death in the absence of its ligand ephrinB3. Upon removal of its ligand, EphA4 triggers cell death that is dependent on caspase activation as caspase inhibitors prevent cell death. EphA4 itself is cleaved by caspase-3-like caspase in the intracellular domain at position D773/774, which is necessary for cell death initiation as mutation of the cleavage site abolishes apoptosis. In the adult subventricular zone, abolishing ephrinB3 results in increased cell death, while the absence of EphA4 results in excessive numbers of neuroblasts. Furthermore, infusion of soluble ephrinB3 into the lateral ventricle reduced cell death, and together these results support a dependence role for EphA4 in adult neurogenesis. (c) 2008 Elsevier B.V. All rights reserved.
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Details
- Title
- EphrinB3 is an anti-apoptotic ligand that inhibits the dependence receptor functions of EphA4 receptors during adult neurogenesis
- Creators
- Celine Furne - Laboratory Apoptosis Cancer and Development, CNRS UMR 5238, Center Léon Bérard, University of Lyon, Lyon, France.Jerome Ricard - University of MiamiJorge Ruben Cabrera - Univ Lyon 1, Lab Apoptosis Canc & Dev, CNRS, UMR 5238,Ctr Leon Berard, F-69365 Lyon, FranceLaurent Pays - Laboratory Apoptosis Cancer and Development, CNRS UMR 5238, Center Léon Bérard, University of Lyon, Lyon, France.John R. Bethea - University of MiamiPatrick Mehlen - Laboratory Apoptosis Cancer and Development, CNRS UMR 5238, Center Léon Bérard, University of Lyon, Lyon, France.Daniel J. Liebl - University of Miami
- Publication Details
- BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, v 1793(2)
- Publisher
- Elsevier
- Number of pages
- 8
- Grant note
- P50NS030291 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) NS049545; P50 NS030291; R01 NS049545-03; NS30291; R01 NS049545; R01 NS049545-04; R01 NS049545-02; R01 NS051709; R01 NS049545-01A1 / NINDS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology; College of Arts and Sciences; Drexel University
- Web of Science ID
- WOS:000263402600002
- Scopus ID
- 2-s2.0-58549109596
- Other Identifier
- 991020100196804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Cell Biology