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Epidemiology and outcomes in patients with severe sepsis admitted to the hospital wards
Journal article   Peer reviewed

Epidemiology and outcomes in patients with severe sepsis admitted to the hospital wards

Stacey-Ann Whittaker, Barry D. Fuchs, David F. Gaieski, Jason D. Christie, Munish Goyal, Nuala J. Meyer, Craig Kean, Dylan S. Small, Scarlett L. Bellamy and Mark E. Mikkelsen
Journal of critical care, v 30(1)
01 Feb 2015
DOI: https://doi.org/10.1016/j.jcrc.2014.07.012
PMID: 25128441
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Critical Care Medicine General & Internal Medicine Life Sciences & Biomedicine Science & Technology
Purpose: The purpose of this study was to detail the trajectory and outcomes of patients with severe sepsis admitted from the emergency department to a non-intensive care unit (ICU) setting and identify risk factors associated with adverse outcomes. Material and methods: This was a single-center retrospective cohort study conducted at a tertiary, academic hospital in the United States between 2005 and 2009. The primary outcome was a composite outcome of ICU transfer within 48 hours of admission and/or 28-day mortality. Results: Of 1853 patients admitted with severe sepsis, 841 (45%) were admitted to a non-ICU setting, the rate increased over time (P < .001), and 12.5% of these patients were transferred to the ICU within 48 hours and/or died within 28 days. In multivariable models, age (P < .001), an oncology diagnosis (P < .001), and illness severity as measured by Acute Physiologic and Chronic Health Evaluation II (P = .04) and high (>= 4 mmol/L) initial serum lactate levels (P = .005) were associated with the primary outcome. Conclusions: Patients presenting to the emergency department with severe sepsis were frequently admitted to a non-ICU setting, and the rate increased over time. Of 8 patients admitted to the hospital ward, one was transferred to the ICU within 48 hours and/or died within 28 days of admission. Factors present at admission were identified that were associated with adverse outcomes. (C) 2014 Elsevier Inc. All rights reserved.

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29 citations in Web of Science
33 citations in Scopus

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Collaboration types
Domestic collaboration
Web of Science research areas
Critical Care Medicine
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