Journal article
Epidemiology of progressive multifocal leukoencephalopathy in the United States: analysis of national mortality and AIDS surveillance data
Neurology, v 41(11), pp 1733-1736
01 Nov 1991
PMID: 1944901
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We analyzed progressive multifocal leukoencephalopathy (PML) mortality data from 1979 to 1987 and data on persons with acquired immunodeficiency syndrome (AIDS) reported to the Centers for Disease Control (CDC). Based on analyses of multiple-cause-of-death vital statistics, deaths related to PML have increased fourfold from 1.5/10,000,000 persons in 1979 to 6.1/10,000,000 persons in 1987. The increase in the PML annual death rate began in 1984, occurred primarily in men 20 to 49 years of age, and was greatest in states known to have a high incidence of AIDS. In 1987, 56% of death certificates that listed PML as a cause of death also listed human immunodeficiency virus (HIV) infection. Analysis of AIDS case reports to the CDC from 1981 through June 1990 demonstrated that 0.72% of persons with AIDS were reported as having PML. Although most persons with AIDS who had PML were 20 to 49 years of age (84.6%), PML was reported more frequently among persons with AIDS greater than or equal to 50 years old than less than 50 years old. In addition, PML was reported more frequently among persons with AIDS who were exposed to HIV by blood transfusion than those in all other exposure categories. These data demonstrate that the increase in PML mortality from 1979 to 1987 was associated with the large increase in immunosuppressed persons with AIDS.
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Details
- Title
- Epidemiology of progressive multifocal leukoencephalopathy in the United States: analysis of national mortality and AIDS surveillance data
- Creators
- R C Holman - United States Department of Health and Human ServicesR S Janssen - United States Department of Health and Human ServicesJ W Buehler - United States Department of Health and Human ServicesM T Zelasky - United States Department of Health and Human ServicesW C Hooper - United States Department of Health and Human Services
- Publication Details
- Neurology, v 41(11), pp 1733-1736
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Health Management and Policy
- Web of Science ID
- WOS:A1991GQ46700005
- Scopus ID
- 2-s2.0-0026090810
- Other Identifier
- 991021895784304721
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- Web of Science research areas
- Clinical Neurology