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Journal article
Epigenetic aging mediates the association between life course socioeconomic status and decrements in kidney function across a decade
GeroScience
12 Jun 2025
PMID: 40500519
Featured in Collection : Research Supported by Drexel Libraries' OA Programs
Abstract
Epigenetic aging measures are novel molecular indicators of biological aging that predict age-related chronic disease. We examined whether several established indices of epigenetic aging mediated the association between life course socioeconomic status (SES) and decrements in kidney function across a decade. Biomarker data were from 252 non-Hispanic (NH) Black and white participants who had consented to genetic analyses in Wave 2 (2004-2009) and 3 (2014-2021) of the Midlife in the United States study (MIDUS). Life course SES included parental education, a proxy of early life SES, and a composite score of adult SES based on the highest education level, household income to poverty line ratio, health insurance coverage, perception of the availability of money to meet needs, and difficulty level paying monthly bills. We included five measures of epigenetic age accelerations (EAA), based on the residuals after each epigenetic clock was regressed on chronological age (Horvath, Horvath blood and skin, Hannum, PhenoAge, and GrimAge) and one measure of the pace of aging (DunedinPACE) obtained during MIDUS 2. Kidney function was based on serum creatinine-based estimated glomerular filtration rate (eGFR), calculated using the CKD-EPI formula (without race adjustment). We calculated absolute decrements in eGFR across 11 years between MIDUS waves 2 and 3. Analyses were adjusted for age, sex, and health-related covariates (currently smoking, obese, hypertension, and insulin resistance). Lower adult SES and accelerated epigenetic aging, especially accelerated GrimAge and faster DunedinPACE pace of aging, mediated the association between lower parental education and larger decrements in eGFR. Accelerated epigenetic aging is associated with larger decrements in kidney function across a decade and may be one of the critical explanatory pathways for the higher burden of chronic kidney disease (CKD) among lower SES individuals.
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Details
- Title
- Epigenetic aging mediates the association between life course socioeconomic status and decrements in kidney function across a decade
- Creators
- Agus Surachman (Corresponding Author) - Drexel University, Epidemiology and BiostatisticsMeera N Harhay - Drexel University, College of MedicineRose Ann DiMaria-Ghalili - Drexel University, College of Nursing and Health ProfessionsAnthony S Zannas - University of North Carolina at Chapel HillDavid M Almeida - Pennsylvania State UniversityChristopher L Coe - University of Wisconsin–Madison
- Publication Details
- GeroScience
- Publisher
- Springer Nature
- Number of pages
- 17
- Grant note
- U54CA267735 / NCI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel FIRST (Center for Firefighter Injury Research and Safety Trends); College of Medicine; Dana and David Dornsife School of Public Health; Epidemiology and Biostatistics; SOM Dean - Research Administration; College of Nursing and Health Professions
- Web of Science ID
- WOS:001506431000001
- Scopus ID
- 2-s2.0-105007870576
- Other Identifier
- 991022057537904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Geriatrics & Gerontology