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Published, Version of Record (VoR)CC BY V4.0, Open
Journal article
Epigenetic silencing of a multifunctional plant stress regulator
eLife, v 8, e47835
2019
PMCID: PMC6739875
PMID: 31418686
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The central regulator of the ethylene (ET) signaling pathway, which controls a plethora of developmental programs and responses to environmental cues in plants, is ETHYLENE-INSENSITIVE2 (EIN2). Here we identify a chromatin-dependent regulatory mechanism at EIN2 requiring two genes: ETHYLENE-INSENSITIVE6 (EIN6), which is a H3K27me3 demethylase also known as RELATIVE OF EARLY FLOWERING6 (REF6), and EIN6 ENHANCER (EEN), the Arabidopsis homolog of the yeast INO80 chromatin remodeling complex subunit IES6 (INO EIGHTY SUBUNIT). Strikingly, EIN6 (REF6) and the INO80 complex redundantly control the level and the localization of the repressive histone modification H3K27me3 and the histone variant H2A. Z at the 5' untranslated region (5'UTR) intron of EIN2. Concomitant loss of EIN6 (REF6) and the INO80 complex shifts the chromatin landscape at EIN2 to a repressive state causing a dramatic reduction of EIN2 expression. These results uncover a unique type of chromatin regulation which safeguards the expression of an essential multifunctional plant stress regulator.
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Details
- Title
- Epigenetic silencing of a multifunctional plant stress regulator
- Creators
- Mark Zander - Salk Institute for Biological StudiesBjörn C Willige - Salk Institute for Biological StudiesYupeng He - Salk Institute for Biological StudiesThu A Nguyen - Salk Institute for Biological StudiesAmber E Langford - Salk Institute for Biological StudiesRamlah Nehring - Salk Institute for Biological StudiesElizabeth Howell - Salk Institute for Biological StudiesRobert McGrath - Drexel UniversityAnna Bartlett - Salk Institute for Biological StudiesRosa Castanon - Salk Institute for Biological StudiesJoseph R Nery - Salk Institute for Biological StudiesHuaming Chen - Salk Institute for Biological StudiesZhuzhu Zhang - Salk Institute for Biological StudiesFlorian Jupe - Salk Institute for Biological StudiesAnna Stepanova - Salk Institute for Biological StudiesRobert J Schmitz - Salk Institute for Biological StudiesMathew G Lewsey - Salk Institute for Biological StudiesJoanne Chory - Salk Institute for Biological StudiesJoseph R Ecker - Salk Institute for Biological Studies
- Publication Details
- eLife, v 8, e47835
- Publisher
- ELIFE SCIENCES PUBLICATIONS LTD; CAMBRIDGE
- Grant note
- National Science Foundation MCB-1024999 Joseph R Ecker; Gordon and Betty Moore Foundation GBMF3034 Joseph R Ecker; Howard Hughes Medical Institute Joseph R Ecker; Deutsche Forschungsgemeinschaft Za-730/1-1 Joanne Chory Joseph R Ecker; Salk Pioneer Postdoctoral Endowment Fund Mark Zander; Human Frontier Science Program LT000222/2013-L Mark Zander; EU 7th Framework Programme EU Marie Curie FP7 International Outgoing Fellowship: 252475 Bjorn C Willige; National Institutes of Health 5R35 GM122604 Mathew G. Lewsey; U.S. Department of Energy DOE FG02 04ER15517 Joanne Chory; The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel University
- Web of Science ID
- WOS:000485691000001
- Scopus ID
- 2-s2.0-85071999087
- Other Identifier
- 991021860714604721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biology