Journal article
Epigenetics, drugs of abuse, and the retroviral promoter
Journal of neuroimmune pharmacology, v 8(5), pp 1181-1196
Dec 2013
PMID: 24218017
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Drug abuse alone has been shown to cause epigenetic changes in brain tissue that have been shown to play roles in addictive behaviors. In conjunction with HIV-1 infection, it can cause epigenetic changes at the viral promoter that can result in altered gene expression, and exacerbate disease progression overall. This review entails an in-depth look at research conducted on the epigenetic effects of three of the most widely abused drugs (cannabinoids, opioids, and cocaine), with a particular focus on the mechanisms through which these drugs interact with HIV-1 infection at the viral promoter. Here we discuss the impact of this interplay on disease progression from the point of view of the nature of gene regulation at the level of chromatin accessibility, chromatin remodeling, and nucleosome repositioning. Given the importance of chromatin remodeling and DNA methylation in controlling the retroviral promoter, and the high susceptibility of the drug abusing population of individuals to HIV infection, it would be beneficial to understand the way in which the host genome is modified and regulated by drugs of abuse.
Metrics
Details
- Title
- Epigenetics, drugs of abuse, and the retroviral promoter
- Creators
- Jasmine Shirazi - Department of Microbiology and Immunology, Drexel Institute for Biotechnology & Virology Research, Drexel University College of Medicine, 3805 Old Easton Road, Doylestown, PA, 18902, USASonia ShahDivya SagarMichael R NonnemacherBrian WigdahlZafar K KhanPooja Jain
- Publication Details
- Journal of neuroimmune pharmacology, v 8(5), pp 1181-1196
- Publisher
- Springer Nature; United States
- Grant note
- R01 CA054559 / NCI NIH HHS R01 AI077414 / NIAID NIH HHS T32 MH079785 / NIMH NIH HHS R21 AI 093172-01 / NIAID NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000328496000016
- Scopus ID
- 2-s2.0-84891372251
- Other Identifier
- 991014877680304721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Neurosciences
- Pharmacology & Pharmacy