Journal article
Epilepsy in systemic autoimmune disorders
Seminars in pediatric neurology, v 21(3), pp 226-231
Sep 2014
PMID: 25510945
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Autoimmunity and inflammation have been implicated as causative factors of seizures and epilepsy. Autoimmune disorders can affect the central nervous system as an isolated syndrome or be part of a systemic disease. Examples of systemic autoimmune disorders include systemic lupus erythematosus, antiphospholipid syndrome, rheumatic arthritis, and Sjögren syndrome. Overall, there is a 5-fold increased risk of seizures and epilepsy in children with systemic autoimmune disorders. Various etiologic factors have been implicated in causing the seizures in these patients, including direct inflammation, effect on blood vessels (vasculitis), and production of autoantibodies. Potential treatments for this autoimmune injury include steroids, immunoglobulins, and other immune-modulatory therapies. A better understanding of the mechanisms of epileptogenesis in patients with systemic autoimmune diseases could lead to targeted treatments and better outcomes.
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Details
- Title
- Epilepsy in systemic autoimmune disorders
- Creators
- Ignacio Valencia - St. Christopher's Hospital for Children
- Publication Details
- Seminars in pediatric neurology, v 21(3), pp 226-231
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000346888000006
- Scopus ID
- 2-s2.0-84916880806
- Other Identifier
- 991019169232304721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Clinical Neurology
- Pediatrics