Journal article
Eradicating Chronic Ear, Nose, and Throat Infections: A Systematically Conducted Literature Review of Advances in Biofilm Treatment
Otolaryngology-head and neck surgery, v 144(3), pp 338-347
01 Mar 2011
PMID: 21493193
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective. Bacteria can grow as individual, planktonic organisms or as complex biofilm communities that are more resistant to treatment. This review was designed to systematically search to identify recent laboratory studies on eradication of biofilms in otolaryngologic infections to highlight promising advances in biofilm treatment.
Data Sources. A systematic electronic literature search of Medline/PubMed, CINHAL, and Web of Science was conducted for articles describing the treatment of biofilm infections in ear, nose, and throat (ENT) diseases through March 2010. English-language articles and articles with an English abstract that focused on biofilm treatment were considered for review.
Review Methods. Each included article was reviewed by one of the authors for study design, treatment intervention, and outcome. Data from in vitro and animal studies were considered separately from human studies.
Results. A total of 30 articles were identified for this review, including 5 studies that included a human treatment component. In general, antibiotics were relatively ineffective for eradicating biofilm infections. Markedly higher antibiotic dosages were required to reduce biofilm presence compared with doses that were effective in eradicating planktonic bacteria. Mupirocin irrigation, gentian violet, and thiamphenicol glycinate acetylcysteine effectively eradicated biofilms. Physical disruption, surfactants, and probiotics were also shown to be beneficial in both nonhuman and human studies.
Conclusion. Eradicating ENT biofilms is difficult when treating single-organism or mixed flora biofilms. Antibiotic therapy is often ineffective against biofilms, and clinical treatment may need to focus on nonantibiotic therapies that reduce, disrupt, or eradicate ENT biofilms.
Metrics
Details
- Title
- Eradicating Chronic Ear, Nose, and Throat Infections: A Systematically Conducted Literature Review of Advances in Biofilm Treatment
- Creators
- Angelia Smith - Allegheny General HospitalFarrel Joel Buchinsky - Allegheny General HospitalJ. Christopher Post - Allegheny General Hospital
- Publication Details
- Otolaryngology-head and neck surgery, v 144(3), pp 338-347
- Publisher
- Sage
- Number of pages
- 10
- Grant note
- Allegheny Singer Research Institute Merck Co.; Merck & Company
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Otolaryngology (and Head and Neck Surgery)
- Web of Science ID
- WOS:000293997400002
- Scopus ID
- 2-s2.0-79959797242
- Other Identifier
- 991020200888004721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Otorhinolaryngology
- Surgery