Journal article
ErbB-2 protein levels in healthy, asymptomatic women
Biomarkers, v 1(2), pp 141-143
01 Jan 1996
PMID: 23888925
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Recently, a number of studies have found a relationship between having breast cancer and elevated serological levels of the extracellular domain (ECD) of the erbB-2 protein. This study focuses on healthy, asymptomatic women, and evaluates the relationship between serological concentration of the ECD of erbB-2 protein and the following parameters: age, ethnicity, smoking status, age at menarche, age at first live birth, menopausal status, whether surgery had been performed within the prior year, history of breast cancer, history of any other cancer, family history of breast cancer, history of other cancers in first degree relatives, and number of prior benign breast biopsies. Blood samples were stored at -70°C and analysed within 3 weeks of phlebotomy. Statistical analysis indicates that in healthy women, the level of erbB-2 protein in the blood is directly related to age (p = 0.0002) and inversely related to having had a live birth (p = 0.018). The relationship to age is independent of the association between the oncoprotein level and menopausal status. The data indicate that rather than having only one threshold value for serological erbB-2 positivity, it may be necessary to have values that reflect age and nulliparity status.
Metrics
Details
- Title
- ErbB-2 protein levels in healthy, asymptomatic women
- Creators
- Brenda BreuerSteven SmithMichael P. OsborneRache M. SimmonsWalter P. CarneyPaul W. Brandt-Rauf
- Publication Details
- Biomarkers, v 1(2), pp 141-143
- Publisher
- Taylor & Francis
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; Drexel University
- Web of Science ID
- WOS:A1996VV68500010
- Scopus ID
- 2-s2.0-0343957452
- Other Identifier
- 991019323677404721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biotechnology & Applied Microbiology
- Toxicology