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Erythropoietin Receptor Positive Circulating Progenitor Cells and Endothelial Progenitor Cells in Patients with Different Stages of Diabetic Retinopathy
Journal article   Peer reviewed

Erythropoietin Receptor Positive Circulating Progenitor Cells and Endothelial Progenitor Cells in Patients with Different Stages of Diabetic Retinopathy

Liu-mei Hu, Xia Lei, Bo Ma, Yu Zhang, Yan Yan, Ya-lan Wu, Ge-zhi Xu, Wen Ye, Ling Wang, Guo-xu Xu, …
Chinese medical sciences journal, v 26(2), pp 69-76
Jun 2011
DOI: https://doi.org/10.1016/S1001-9294(11)60023-0
PMID: 21703113

Abstract

circulating progenitor cells endothelial progenitor cells erythropoietin receptor Diabetic Retinopathy
Objective To investigate the possible involvement of erythropoietin (EPO)/erythropoietin receptor (EPOR) system in neovascularization and vascular regeneration in diabetic retinopathy (DR). Methods EPOR positive circulating progenitor cells (CPCs: CD34+) and endothelial progenitor cells (EPCs: CD34+KDR+) were assessed by flow cytometry in type 2 diabetic patients with different stages of DR. The cohort consisted of age- and sex-matched control patients without diabetes (n=7), non-proliferative DR (NPDR, n=7), proliferative DR (PDR, n=8), and PDR complicated with diabetic nephropathy (PDR-DN, n=7). Results The numbers of EPOR+ CPCs and EPOR+ EPCs were reduced remarkably in NPDR compared with the control group (both P<0.01), whereas rebounded in PDR and PDR-DN groups in varying degrees. Similar changes were observed in respect of the proportion of EPOR+ CPCs in CPCs (NPDR vs. control, P<0.01) and that of EPOR+ EPCs in EPCs (NPDR vs. control, P<0.05). Conclusion Exogenous EPO, mediated via the EPO/EPOR system of EPCs, may alleviate the impaired vascular regeneration in NPDR, whereas it might aggravate retinal neovascularization in PDR due to a rebound of EPOR+ EPCs associated with ischemia.

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