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Escherichia coli Expressing a Neisseria gonorrhoeae Opacity-Associated Outer Membrane Protein Invade Human Cervical and Endometrial Epithelial Cell Lines
Journal article   Open access

Escherichia coli Expressing a Neisseria gonorrhoeae Opacity-Associated Outer Membrane Protein Invade Human Cervical and Endometrial Epithelial Cell Lines

Daniel Simon and Richard Rest
Proceedings of the National Academy of Sciences - PNAS, v 89(12), pp 5512-5516
15 Jun 1992
PMID: 1608963
url
https://doi.org/10.1073/pnas.89.12.5512View
Published, Version of Record (VoR)Open Access (License Unspecified) Open

Abstract

Cellular biology Medical immunity Proteins Sexually transmitted diseases STD
  Members of the opacity-associated (Opa) outer membrane protein family of Neisseria gonorrhoeae have been proposed to mediate adherence to and invasion of cultured human epithelial cells. Escherichia coli was transformed with a plasmid containing a gonococcal opa gene fused in-frame to the leader sequence of the beta-lactamase gene as described by Palmer and others, and the findings indicate that at least one gonococcal Opa protein is an invasin.

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Immunology
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