Escherichia coli Expressing a Neisseria gonorrhoeae Opacity-Associated Outer Membrane Protein Invade Human Cervical and Endometrial Epithelial Cell Lines
Cellular biology Medical immunity Proteins Sexually transmitted diseases STD
Members of the opacity-associated (Opa) outer membrane protein family of Neisseria gonorrhoeae have been proposed to mediate adherence to and invasion of cultured human epithelial cells. Escherichia coli was transformed with a plasmid containing a gonococcal opa gene fused in-frame to the leader sequence of the beta-lactamase gene as described by Palmer and others, and the findings indicate that at least one gonococcal Opa protein is an invasin.
Escherichia coli Expressing a Neisseria gonorrhoeae Opacity-Associated Outer Membrane Protein Invade Human Cervical and Endometrial Epithelial Cell Lines
Creators
Daniel Simon - Hahnemann University Hospital
Richard Rest - Hahnemann University Hospital
Publication Details
Proceedings of the National Academy of Sciences - PNAS, v 89(12), pp 5512-5516
Publisher
National Academy of Sciences
Resource Type
Journal article
Language
English
Academic Unit
[Retired Faculty]
Web of Science ID
WOS:A1992HY05300064
Scopus ID
2-s2.0-0026780391
Other Identifier
991019184032004721
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