Journal article
Esophageal Intraepithelial Eosinophils in Dysphagic Patients with Gastroesophageal Reflux Disease
Digestive diseases and sciences, v 55(4), pp 967-972
01 Apr 2010
PMID: 19960255
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background Patients with gastroesophageal reflux disease (GERD) often complain of dysphagia and are frequently found to have intraepithelial eosinophils on esophageal biopsy.
Aim The aim of this study was to investigate the relationship between dysphagia and the number of intraepithelial eosinophils in patients with GERD.
Methods Review of all patients studied in our esophageal function laboratory from 1999 to 2007 identified 1,533 patients with increased esophageal acid exposure. Patients who complained of dysphagia without mechanical or motor causes were identified and divided into three groups based on whether dysphagia was their primary, secondary or tertiary symptom. A control group consisted of randomly selected GERD patients with no dysphagia. The highest number of intraepithelial eosinophils per high-power field (HPF) in biopsies from the squamocolumnar junction (SCJ) and esophageal body was compared across groups.
Results There were 71 patients with unexplained dysphagia. Dysphagia was the primary symptom in 13 (18%), secondary symptom in 34 (48%), and tertiary symptom in 24 (34%) patients. The number of eosinophils differed between the four groups, with the highest number in those with dysphagia as the primary symptom (P = 0.0007). This relationship persisted whether biopsies were from the SCJ (P = 0.0057) or esophageal body (P = 0.0096).
Conclusion An association exists between the number of intraepithelial eosinophils and dysphagia in GERD patients, with the highest number of eosinophils in those with the primary symptom of dysphagia.
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Details
- Title
- Esophageal Intraepithelial Eosinophils in Dysphagic Patients with Gastroesophageal Reflux Disease
- Creators
- Shahin Ayazi - University of Southern CaliforniaJeffrey A. Hagen - University of Southern CaliforniaParakrama Chandrasoma - University of Southern CaliforniaParviz Gholami - University of Southern CaliforniaJoerg Zehetner - University of Southern CaliforniaArzu Oezcelik - University of Southern CaliforniaJohn C. Lipham - University of Southern CaliforniaSteven R. DeMeester - University of Southern CaliforniaTom R. DeMeester - University of Southern CaliforniaMichael M. Kline - University of Southern California
- Publication Details
- Digestive diseases and sciences, v 55(4), pp 967-972
- Publisher
- Springer Nature
- Number of pages
- 6
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Surgery
- Web of Science ID
- WOS:000276153900014
- Scopus ID
- 2-s2.0-77950343689
- Other Identifier
- 991022048374904721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Gastroenterology & Hepatology