Journal article
Establishing a relationship between bacteria in the human gut and Complex Regional Pain Syndrome
Brain, behavior, and immunity, Vol.29, pp.62-69
Mar 2013
PMID: 23261776
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
► Study compares GI microbial communities of CRPS & Control subjects. ► Bacterial sequences are procured using 454 sequencing (16s rRNA). ► CRPS GI bacterial communities differ in phylogenies when compared to controls. ► CRPS GI bacterial communities differ in diversity when compared to controls.
Complex Regional Pain Syndrome (CRPS) is a serious and painful condition involving the peripheral and central nervous systems. Full comprehension of the disorder’s pathophysiology remains incomplete, but research implicates the immune system as a contributor to chronic pain. Because of the impact gastrointestinal bacteria have in the development and behavior of the immune system, this study compares the GI microbial communities of 16 participants with CRPS (5 of whom have intestinal discomforts) and 16 healthy controls using 454 sequencing technology. CRPS subjects were found to have significantly less diversity than their healthy counterparts. Statistical analysis of the phylogenetic classifications revealed significantly increased levels of Proteobacteria and decreased levels of Firmicutes in CRPS subjects. Clustering analysis showed significant separation between healthy controls and CRPS subjects. These results support the hypothesis that the GI microbial communities of CRPS participants differ from those of their healthy counterparts. These variations may hold the key to understanding how CRPS develops and provide information that could yield a potential treatment.
Metrics
8 Record Views
Details
- Title
- Establishing a relationship between bacteria in the human gut and Complex Regional Pain Syndrome
- Creators
- Erin R Reichenberger - School of Biomedical Engineering, Science and Health Systems, Drexel University, United StatesGuillermo M Alexander - Department of Neurology, Drexel University College of Medicine, United StatesMarielle J Perreault - Department of Neurology, Drexel University College of Medicine, United StatesJacob A Russell - Department of Biology, Drexel University, United StatesRobert J Schwartzman - Department of Neurology, Drexel University College of Medicine, United StatesUri Hershberg - School of Biomedical Engineering, Science and Health Systems, Drexel University, United StatesGail Rosen - Department of Electrical and Computer Engineering, Drexel University, United States
- Publication Details
- Brain, behavior, and immunity, Vol.29, pp.62-69
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology; Electrical and Computer Engineering; School of Biomedical Engineering, Science, and Health Systems; Neurology
- Identifiers
- 991014877920604721
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Web of Science research areas
- Immunology
- Neurosciences
- Psychiatry