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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Establishment of a consensus protocol to explore the brain pathobiome in patients with mild cognitive impairment and Alzheimer's disease: Research outline and call for collaboration
Alzheimer's & dementia, v 19(iss 11), pp 5209-5231
07 Jun 2023
PMID: 37283269
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Microbial infections of the brain can lead to dementia, and for many decades microbial infections have been implicated in Alzheimer's disease (AD) pathology. However, a causal role for infection in AD remains contentious, and the lack of standardized detection methodologies has led to inconsistent detection/identification of microbes in AD brains. There is a need for a consensus methodology; the Alzheimer's Pathobiome Initiative aims to perform comparative molecular analyses of microbes in post mortem brains versus cerebrospinal fluid, blood, olfactory neuroepithelium, oral/nasopharyngeal tissue, bronchoalveolar, urinary, and gut/stool samples. Diverse extraction methodologies, polymerase chain reaction and sequencing techniques, and bioinformatic tools will be evaluated, in addition to direct microbial culture and metabolomic techniques. The goal is to provide a roadmap for detecting infectious agents in patients with mild cognitive impairment or AD. Positive findings would then prompt tailoring of antimicrobial treatments that might attenuate or remit mounting clinical deficits in a subset of patients.
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Details
- Title
- Establishment of a consensus protocol to explore the brain pathobiome in patients with mild cognitive impairment and Alzheimer's disease: Research outline and call for collaboration
- Creators
- Richard Lathe - University of EdinburghNikki M Schultek - Intracell Research Group, Wake Forest, North Carolina, USABrian J Balin - Philadelphia College of Osteopathic MedicineGarth D Ehrlich - Drexel UniversityLavinia Alberi Auber - VitalizeDx, Epalanges, SwitzerlandGeorge Perry - The University of Texas at San AntonioEdward B Breitschwerdt - North Carolina State UniversityDavid B Corry - Baylor College of MedicineRichard L Doty - University of PennsylvaniaRobert A Rissman - University of California San DiegoPeter L Nara - BIO (Canada)Ruth Itzhaki - University of OxfordWilliam A Eimer - Massachusetts General HospitalRudolph E Tanzi - Massachusetts General HospitalIntracell Research Group Consortium Collaborators
- Publication Details
- Alzheimer's & dementia, v 19(iss 11), pp 5209-5231
- Publisher
- eScholarship, University of California
- Number of pages
- 23
- Grant note
- P30 AG062429 / NIA NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:001002689800001
- Scopus ID
- 2-s2.0-85163127233
- Other Identifier
- 991020631687404721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Clinical Neurology