Journal article
Estimating frontal and parietal involvement in cognitive estimation: a study of focal neurodegenerative diseases
Frontiers in human neuroscience, v 9(JUNE), pp 317-317
04 Jun 2015
PMID: 26089786
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We often estimate an unknown value based on available relevant information, a process known as cognitive estimation. In this study, we assess the cognitive and neuroanatomic basis for quantitative estimation by examining deficits in patients with focal neurodegenerative disease in frontal and parietal cortex. Executive function and number knowledge are key components in cognitive estimation. Prefrontal cortex has been implicated in multilevel reasoning and planning processes, and parietal cortex has been associated with number knowledge required for such estimations. We administered the Biber cognitive estimation test (BCET) to assess cognitive estimation in 22 patients with prefrontal disease due to behavioral variant frontotemporal dementia (bvFTD), to 17 patients with parietal disease due to corticobasal syndrome (CBS) or posterior cortical atrophy (PCA) and 11 patients with mild cognitive impairment (MCI). Both bvFTD and CBS/PCA patients had significantly more difficulty with cognitive estimation than controls. MCI were not impaired on BCET relative to controls. Regression analyses related BCET performance to gray matter atrophy in right lateral prefrontal and orbital frontal cortices in bvFTD, and to atrophy in right inferior parietal cortex, right insula, and fusiform cortices in CBS/PCA. These results are consistent with the hypothesis that a frontal-parietal network plays a crucial role in cognitive estimation.
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Details
- Title
- Estimating frontal and parietal involvement in cognitive estimation: a study of focal neurodegenerative diseases
- Creators
- Teagan A. Bisbing - University of PennsylvaniaChristopher A. Olm - University of PennsylvaniaCorey T. McMillan - University of PennsylvaniaKatya Rascovsky - University of PennsylvaniaLaura Baehr - University of PennsylvaniaKylie Ternes - University of PennsylvaniaDavid J. Irwin - University of PennsylvaniaRobin Clark - University of PennsylvaniaMurray Grossman - University of Pennsylvania
- Publication Details
- Frontiers in human neuroscience, v 9(JUNE), pp 317-317
- Publisher
- Frontiers Research Foundation
- Number of pages
- 11
- Grant note
- R01NS044266 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) Wyncote Foundation P01AG032953 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) AG017586; NS044266; AG032953; AG043503; NS053488 / National Institute of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Physical Therapy (and Rehabilitation Sciences)
- Web of Science ID
- WOS:000356075100001
- Scopus ID
- 2-s2.0-84933673868
- Other Identifier
- 991021894091704721
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- Web of Science research areas
- Neurosciences
- Psychology