Journal article
Estimation of a Safe Level for Occupational Exposure to Vinyl Chloride Using a Benchmark Dose Method in Central China
Journal of occupational health, v 54(4)
Jul 2012
PMID: 22672882
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Estimation of a Safe Level for Occupational Exposure to Vinyl Chloride Using a Benchmark Dose Method in Central China: Jie JIAO, et al. Department of Occupational Health and Toxicology, School of Public Health, Fudan University, China—
Objectives
The aim of this study was to estimate a benchmark dose (BMD) for chromosome damage induced by vinyl chloride monomer (VCM) in VCMexposed workers in central China and validate the published results in Shanghai.
Methods
VCMexposed workers who had been exposed to VCM for at least one year (n=463) and matched subjects not exposed to VCM or other toxins (n=273) were asked to participate in this study. Micronucleus (MN) frequency based on the cytokinesis‐block micronucleus assay (CBMN) was used as a biomarker for chromosome damage induced by VCM exposure.
Results
The MN frequency in the VCM‐exposed workers was significantly higher than that in the control group, and multivariate Poisson regression suggested that gender, smoking status and VCM exposure were the significant factors influencing the risk of increased MN frequency. When subjects were further stratified according to gender and smoking status, the results showed that female VCMexposed workers were more susceptible than the males to the risk of increased MN frequency. The MN frequency of smokers was significantly higher than that of nonsmokers in the control group. Our study also suggested that there was a strong dose‐response relationship between VCM CED and the increased risk of MN frequency in the total group, males and females. The BMDL10 was found to be 630.6, 670.2 and 273.7 mgyear for all VCM‐exposed workers, males and females, respectively.
Conclusions
These results invite further scrutiny of the current VCM occupational exposure limits and warrant further study of the risk of VCM genotoxicity and carcinogenicity.
Metrics
Details
- Title
- Estimation of a Safe Level for Occupational Exposure to Vinyl Chloride Using a Benchmark Dose Method in Central China
- Creators
- Jie Jiao - Fudan UniversityNan‐nan Feng - School of Public Health, Fudan UniversityYong Li - Fudan UniversityYuan Sun - Fudan UniversityWu Yao - Zhengzhou UniversityWei Wang - Zhengzhou UniversityGuang‐hui Zhang - School of Public Health, Fudan UniversityShi‐yi Sun - Institute of Occupational MedicineHong‐shan Tan - School of Public Health, Fudan UniversityQi Wang - Fudan UniversityYiliang Zhu - Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, USAYongliang Li - University of Illinois at ChicagoPaul W. Brandt‐Rauf - School of Public Health, University of Illinois at ChicagoZhao‐lin Xia - School of Public Health, Fudan UniversityHenan Institute of Occupational Health
- Publication Details
- Journal of occupational health, v 54(4)
- Number of pages
- 8
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000307145200002
- Scopus ID
- 2-s2.0-84867347646
- Other Identifier
- 991019176800404721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health