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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Estimation of benchmark dose for micronucleus occurrence in Chinese vinyl chloride-exposed workers
International journal of hygiene and environmental health, v 216(1), pp 76-81
Jan 2013
PMID: 22425610
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In this study, we estimated the possibility of using benchmark dose (BMD) to assess the dose–response relationship between vinyl chloride monomer (VCM) exposure and chromosome damage. A group of 317 workers occupationally exposed to vinyl chloride monomer and 166 normal, unexposed control in Shandong Province northern China were examined for chromosomal damage in peripheral blood lymphocytes (PBL) using the cytokinesis-blocked micronucleus (CB-MN) assay of DNA damage. The exposed group (3.47±2.65)‰ showed higher micronucleus frequency than the control (1.60±1.30)‰ (P<0.01). Occupational exposure level based on micronucleus occurrence in all individuals was analyzed with benchmark dose (BMD) methods. The benchmark dose lower limit of a one-sided 95% confidence interval (BMDL) for 10% excess risk was also determined. Results showed a dose–response relationship between cumulative exposure and MN frequency, and a BMDL of 0.54mg/m3 and 0.23mg/m3 for males and females, respectively. Female workers were more susceptible to MN damage than male workers.
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Details
- Title
- Estimation of benchmark dose for micronucleus occurrence in Chinese vinyl chloride-exposed workers
- Creators
- Qi Wang - Fudan UniversityHong-shan Tan - Fudan UniversityXiao-ming Ma - Tianjin Medical UniversityYuan Sun - Fudan UniversityNan-nan Feng - Fudan UniversityLi-fang Zhou - Fudan UniversityYun-jie Ye - Fudan UniversityYi-liang Zhu - University of South FloridaYong-liang Li - School of Public Health, University of Illinois at Chicago, 1603 West Taylor Street, Chicago, IL 60612, USAPaul W. Brandt-Rauf - University of Illinois ChicagoNai-jun Tang - Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin 300070, ChinaZhao-lin Xia - Fudan University
- Publication Details
- International journal of hygiene and environmental health, v 216(1), pp 76-81
- Publisher
- Elsevier GmbH
- Grant note
- R01-OH04192; P30-ES09089 / NIH 08GWD12; 08GW2X0402 / Shanghai Bureau of Public Health NSFC30671740 / National Natural Science Foundation of China
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000313766300010
- Scopus ID
- 2-s2.0-84870246011
- Other Identifier
- 991019176798604721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Infectious Diseases
- Public, Environmental & Occupational Health