Journal article
Estrogen administration increases neuronal responses to excitatory amino acids as a long-term effect
Brain research, v 503(2), pp 354-357
1989
PMID: 2691019
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Ongoing studies from this laboratory have demonstrated marked potentiating actions of the sex steroid 17β-estradiol (E
2) on glutamate-induced excitation. In the present study, systemic injection of a physiological dose fo E
2 was demonstrated to augment significantly excitatory responses of cerebellar Purkinje (Pnj) cells to iontophoretic application of the specific excitatory amino acid (e.a.a.) agonists quisqualate and
N-
methyl-
d-aspartate
. Potentiation of e.a.a. responses was observed as rapidly as 5–10 min post E
2, and was, in many cases, a persistent, non-decremental effect. These observed long-term actions of E
2 may provide one mechanism for the activating effects of the steroid on sensorimotor function and acitivity.
Metrics
Details
- Title
- Estrogen administration increases neuronal responses to excitatory amino acids as a long-term effect
- Creators
- Sheryl S. Smith - Hahnemann University HospitalSusan S Smith - [Retired Faculty]
- Publication Details
- Brain research, v 503(2), pp 354-357
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:A1989CC82800031
- Scopus ID
- 2-s2.0-0024343839
- Other Identifier
- 991019184183604721
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- Web of Science research areas
- Neurosciences