Journal article
Etiologic heterogeneity among non-Hodgkin lymphoma subtypes: the InterLymph Non-Hodgkin Lymphoma Subtypes Project
Journal of the National Cancer Institute. Monographs, v 2014(48), pp 130-144
Aug 2014
PMID: 25174034
Abstract
Non-Hodgkin lymphoma (NHL) comprises biologically and clinically heterogeneous subtypes. Previously, study size has limited the ability to compare and contrast the risk factor profiles among these heterogeneous subtypes.
We pooled individual-level data from 17 471 NHL cases and 23 096 controls in 20 case-control studies from the International Lymphoma Epidemiology Consortium (InterLymph). We estimated the associations, measured as odds ratios, between each of 11 NHL subtypes and self-reported medical history, family history of hematologic malignancy, lifestyle factors, and occupation. We then assessed the heterogeneity of associations by evaluating the variability (Q value) of the estimated odds ratios for a given exposure among subtypes. Finally, we organized the subtypes into a hierarchical tree to identify groups that had similar risk factor profiles. Statistical significance of tree partitions was estimated by permutation-based P values (P NODE).
Risks differed statistically significantly among NHL subtypes for medical history factors (autoimmune diseases, hepatitis C virus seropositivity, eczema, and blood transfusion), family history of leukemia and multiple myeloma, alcohol consumption, cigarette smoking, and certain occupations, whereas generally homogeneous risks among subtypes were observed for family history of NHL, recreational sun exposure, hay fever, allergy, and socioeconomic status. Overall, the greatest difference in risk factors occurred between T-cell and B-cell lymphomas (P NODE < 1.0×10(-4)), with increased risks generally restricted to T-cell lymphomas for eczema, T-cell-activating autoimmune diseases, family history of multiple myeloma, and occupation as a painter. We further observed substantial heterogeneity among B-cell lymphomas (P NODE < 1.0×10(-4)). Increased risks for B-cell-activating autoimmune disease and hepatitis C virus seropositivity and decreased risks for alcohol consumption and occupation as a teacher generally were restricted to marginal zone lymphoma, Burkitt/Burkitt-like lymphoma/leukemia, diffuse large B-cell lymphoma, and/or lymphoplasmacytic lymphoma/Waldenström macroglobulinemia.
Using a novel approach to investigate etiologic heterogeneity among NHL subtypes, we identified risk factors that were common among subtypes as well as risk factors that appeared to be distinct among individual or a few subtypes, suggesting both subtype-specific and shared underlying mechanisms. Further research is needed to test putative mechanisms, investigate other risk factors (eg, other infections, environmental exposures, and diet), and evaluate potential joint effects with genetic susceptibility.
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Details
- Title
- Etiologic heterogeneity among non-Hodgkin lymphoma subtypes: the InterLymph Non-Hodgkin Lymphoma Subtypes Project
- Creators
- Lindsay M Morton - National Institutes of HealthSusan L Slager - Mayo ClinicJames R Cerhan - Mayo ClinicSophia S Wang - City Of Hope National Medical CenterClaire M Vajdic - UNSW SydneyChristine F Skibola - University of AlabamaPaige M Bracci - University of California, San FranciscoSilvia de SanjoséKarin E Smedby - Karolinska InstitutetBrian C H Chiu - University of ChicagoYawei Zhang - Yale UniversitySam M Mbulaiteye - National Institutes of HealthAlain Monnereau - Université de BordeauxJennifer J Turner - Macquarie UniversityJacqueline Clavel - Université Paris-SudHans-Olov Adami - Karolinska InstitutetEllen T Chang - Exponent (United States)Bengt Glimelius - Karolinska InstitutetHenrik Hjalgrim - Statens Serum InstitutMads Melbye - Statens Serum InstitutPaolo CrosignaniSimonetta di Lollo - University of FlorenceLucia MiligiOriana NanniValerio RamazzottiStefania RodellaAdele Seniori CostantiniEmanuele StagnaroRosario TuminoCarla VindigniPaolo Vineis - Imperial College LondonNikolaus Becker - German Cancer Research CenterYolanda BenaventePaolo Boffetta - Icahn School of Medicine at Mount SinaiPaul Brennan - Centre international de recherche sur le cancerPierluigi Cocco - University of CagliariLenka ForetovaMarc Maynadié - Université de BourgogneAlexandra Nieters - University of FreiburgAnthony Staines - Dublin City UniversityJoanne S Colt - National Institutes of HealthWendy Cozen - University of Southern CaliforniaScott Davis - University of WashingtonAnneclaire J de Roos - Drexel UniversityPatricia Hartge - National Institutes of HealthNathaniel Rothman - National Institutes of HealthRichard K Severson - Wayne State UniversityElizabeth A Holly - University of California, San FranciscoTimothy G Call - Mayo ClinicAndrew L Feldman - Mayo ClinicThomas M Habermann - Mayo ClinicMark Liebow - Mayo ClinicAaron Blair - National Institutes of HealthKenneth P Cantor - National Institutes of HealthEleanor V Kane - University of YorkTracy Lightfoot - University of YorkEve Roman - University of YorkAlex Smith - University of YorkAngela Brooks-Wilson - Simon Fraser UniversityJoseph M Connors - University of British ColumbiaRandy D Gascoyne - University of British ColumbiaJohn J Spinelli - University of British ColumbiaBruce K Armstrong - The University of SydneyAnne Kricker - The University of SydneyTheodore R Holford - Yale UniversityQing Lan - National Institutes of HealthTongzhang Zheng - Yale UniversityLaurent Orsi - Université Paris-SudLuigino Dal MasoSilvia Franceschi - Centre international de recherche sur le cancerCarlo La Vecchia - Mario Negri Institute for Pharmacological ResearchEva Negri - Mario Negri Institute for Pharmacological ResearchDiego SerrainoLeslie Bernstein - City Of Hope National Medical CenterAlexandra Levine - City Of Hope National Medical CenterJonathan W Friedberg - University of RochesterJennifer L KellySonja I Berndt - National Institutes of HealthBrenda M Birmann - Harvard UniversityChristina A Clarke - Cancer Prevention Institute of CaliforniaChristopher R Flowers - Emory UniversityJames M Foran - Mayo ClinicMarshall E Kadin - Boston UniversityOra PaltielDennis D Weisenburger - City Of Hope National Medical CenterMartha S Linet - National Institutes of HealthJoshua N Sampson - National Institutes of Health
- Publication Details
- Journal of the National Cancer Institute. Monographs, v 2014(48), pp 130-144
- Publisher
- Oxford University Press
- Grant note
- UL1 TR000142 / NCATS NIH HHS K23 CA102216 / NCI NIH HHS N01-PC-67008 / NCI NIH HHS CA150037 / NCI NIH HHS P30 CA033572 / NCI NIH HHS CA165923 / NCI NIH HHS N01-CP-ES-11027 / NCI NIH HHS R01CA50850 / NCI NIH HHS CA143947 / NCI NIH HHS P50 CA097274 / NCI NIH HHS Canadian Institutes of Health Research Intramural NIH HHS R01 CA92153-S1 / NCI NIH HHS P50 CA130805 / NCI NIH HHS UL 1 RR024160 / NCRR NIH HHS N01-PC-65064 / NCI NIH HHS R01 CA14690 / NCI NIH HHS R01CA154643-01A1 / NCI NIH HHS T32 HL007152 / NHLBI NIH HHS R01CA92153 / NCI NIH HHS R01CA122663 / NCI NIH HHS P50 CA97274 / NCI NIH HHS R01CA087014 / NCI NIH HHS CA51086 / NCI NIH HHS CA62006 / NCI NIH HHS N02-PC-71105 / NCI NIH HHS UL1 TR000135 / NCATS NIH HHS R01CA104682 / NCI NIH HHS N01-CO-12400 / NCI NIH HHS R03CA132153 / NCI NIH HHS UL1 TR000430 / NCATS NIH HHS R03CA125831 / NCI NIH HHS UL1 TR000042 / NCATS NIH HHS R01 CA149445 / NCI NIH HHS N01-CP-95618 / NCI NIH HHS N01-PC-67010 / NCI NIH HHS R01CA45614 / NCI NIH HHS U01 CA118444 / NCI NIH HHS P30 CA016359 / NCI NIH HHS R13 CA159842 01 / NCI NIH HHS 5R01 CA69669-02 / NCI NIH HHS R01CA100555 / NCI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Scopus ID
- 2-s2.0-84906833192
- Other Identifier
- 991020099920904721