Journal article
Etiologic heterogeneity among non-Hodgkin lymphoma subtypes
Blood, v 112(13), pp 5150-5160
15 Dec 2008
PMID: 18796628
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Understanding patterns of etiologic commonality and heterogeneity for non-Hodgkin lymphomas may illuminate lymphomagenesis. We present the first systematic comparison of risks by lymphoma subtype for a broad range of putative risk factors in a population-based case-control study, including diffuse large B-cell (DLBCL; N = 416), follicular (N = 318), and marginal zone lymphomas (N = 106), and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL; N = 133). We required at least 2 of 3 analyses to support differences in risk: (1) polytomous logistic regression, (2) homogeneity tests, or (3) dichotomous logistic regression, analyzing all 7 possible pairwise comparisons among the subtypes, corresponding to various groupings by clinical behavior, genetic features, and differentiation. Late birth order and high body mass index (≥ 35) kg/m
2
) increased risk for DLBCL alone. Autoimmune conditions increased risk for marginal zone lymphoma alone. The tumor necrosis factor G-308A polymorphism (rs1800629) increased risks for both DLBCL and marginal zone lymphoma. Exposure to certain dietary heterocyclic amines from meat consumption increased risk for CLL/SLL alone. We observed no significant risk factors for follicular lymphoma alone. These data clearly support both etiologic commonality and heterogeneity for lymphoma subtypes, suggesting that immune dysfunction is of greater etiologic importance for DLBCL and marginal zone lymphoma than for CLL/SLL and follicular lymphoma.
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Details
- Title
- Etiologic heterogeneity among non-Hodgkin lymphoma subtypes
- Creators
- Lindsay M. Morton - National Institutes of HealthSophia S. Wang - National Institutes of HealthWendy Cozen - University of Southern CaliforniaMartha S. Linet - National Institutes of HealthNilanjan Chatterjee - National Institutes of HealthScott Davis - University of WashingtonRichard K. Severson - Wayne State UniversityJoanne S. Colt - National Institutes of HealthMohammad A. Vasef - University of New MexicoNathaniel Rothman - National Institutes of HealthAaron Blair - National Institutes of HealthLeslie Bernstein - City Of Hope National Medical CenterAmanda J. Cross - National Institutes of HealthAnneclaire J. De Roos - University of WashingtonEric A. Engels - National Institutes of HealthDavid W. Hein - University of Louisville HospitalDeirdre A. Hill - University of New MexicoLinda E. Kelemen - Mayo Clinic College of Medicine Rochester, MNUnhee Lim - National Institutes of HealthCharles F. Lynch - University of IowaMaryjean Schenk - The Barbara Ann Karmanos Cancer InstituteSholom Wacholder - National Institutes of HealthMary H. Ward - National Institutes of HealthShelia Hoar Zahm - National Institutes of HealthStephen J. Chanock - National Institutes of HealthJames R. Cerhan - Mayo ClinicPatricia Hartge - National Institutes of Health
- Publication Details
- Blood, v 112(13), pp 5150-5160
- Series
- Neoplasia
- Publisher
- American Society of Hematology
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000261513400048
- Scopus ID
- 2-s2.0-58149384454
- Other Identifier
- 991020100052004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Hematology