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Etiology of Genital Ulcers and Prevalence of Human Immunodeficiency Virus Coinfection in 10 US Cities
Journal article   Open access   Peer reviewed

Etiology of Genital Ulcers and Prevalence of Human Immunodeficiency Virus Coinfection in 10 US Cities

Kristen J. Mertz, David Trees, William C. Levine, Joel S. Lewis, Billy Litchfield, Kevin S. Pettus, Stephen A. Morse, Michael E. St. Louis, Judith B. Weiss, Jane Schwebke, …
The Journal of infectious diseases, v 178(6), pp 1795-1798
Dec 1998
PMID: 9815237
url
https://doi.org/10.1086/314502View
Published, Version of Record (VoR)Maybe Open Access (Publisher Bronze) Open

Abstract

To determine the etiology of genital ulcers and to assess the prevalence of human immunodeficiency virus (HIV) infection in ulcer patients in 10 US cities, ulcer and serum specimens were collected from ∼50 ulcer patients at a sexually transmitted disease clinic in each city. Ulcer specimens were tested using a multiplex polymerase chain reaction assay to detect Haemophilus ducreyi, Treponema pallidum, and herpes simplex virus (HSV); sera were tested for antibody to HIV. H. ducreyi was detected in ulcer specimens from patients in Memphis (20% of specimens) and Chicago (12%). T. pallidum was detected in ulcer specimens from every city except Los Angeles (median, 9% of specimens; range, 0%–46%). HSV was detected in ≥50% of specimens from all cities except Memphis (42%). HIV seroprevalence in ulcer patients was 6% (range by city, 0%–18%). These data suggest that chancroid is prevalent in some US cities and that persons with genital ulcers should be a focus of HIV prevention activities.

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Collaboration types
Industry collaboration
Domestic collaboration
Web of Science research areas
Immunology
Infectious Diseases
Microbiology
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