Journal article
European Population Substructure Correlates with Systemic Lupus Erythematosus Endophenotypes in North Americans of European Descent
Genes and immunity, v 11(6), pp 515-521
01 Sep 2010
PMID: 19847193
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Previous work has demonstrated that northern and southern European ancestries are associated with specific systemic lupus erythematosus (SLE) manifestations. Here, 1855 SLE cases of European descent were genotyped for 4965 single nucleotide polymorphisms and principal components analysis of genotype information was used to define population substructure. The first principal component (PC1) distinguished northern from southern European ancestry, PC2 differentiated eastern from western European ancestry, and PC3 delineated Ashkenazi Jewish ancestry. Compared to northern European ancestry, southern European ancestry was associated with autoantibody production (OR=1.40, 95% CI 1.07-1.83) and renal involvement (OR 1.41, 95% CI 1.06-1.87), and was protective for discoid rash (OR=0.51, 95% CI 0.32-0.82) and photosensitivity (OR=0.74, 95% CI 0.56-0.97). Both serositis (OR=1.46, 95% CI 1.12-1.89) and autoantibody production (OR=1.38, 95% CI 1.06-1.80) were associated with Western compared to Eastern European ancestry. Ashkenazi Jewish ancestry was protective against neurologic manifestations of SLE (OR=0.62, 95% CI 0.40-0.94). Homogeneous clusters of cases defined by multiple PCs demonstrated stronger phenotypic associations. Genetic ancestry may contribute to the development of SLE endophenotypes and should be accounted for in genetic studies of disease characteristics.
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Details
- Title
- European Population Substructure Correlates with Systemic Lupus Erythematosus Endophenotypes in North Americans of European Descent
- Creators
- Ilana B. Richman - University of California, San FranciscoSharon A. Chung - University of California, San FranciscoKimberly E. Taylor - University of California, San FranciscoRoman Kosoy - University of California, DavisChao Tian - University of California, DavisWard A. Ortmann - GenentechJoanne Nititham - University of California, San FranciscoAnnette T. Lee - Northwell HealthSarah Rutman - University of PittsburghMichelle Petri - Johns Hopkins MedicineSusan Manzi - University of PittsburghTimothy W. Behrens - GenentechPeter K. Gregersen - Northwell HealthMichael F. Seldin - University of California, DavisLindsey A. Criswell - University of California, San Francisco
- Publication Details
- Genes and immunity, v 11(6), pp 515-521
- Publisher
- Springer Nature
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- General Internal Medicine
- Web of Science ID
- WOS:000281563400009
- Scopus ID
- 2-s2.0-77956342587
- Other Identifier
- 991021933909404721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Genetics & Heredity
- Immunology