Files and links (1)
Accepted (AM)Open Access (License Unspecified), Open
Journal article
Evaluating changes in tendon crimp with fatigue loading as an ex vivo structural assessment of tendon damage
Journal of orthopaedic research, v 33(6), pp 904-910
Jun 2015
PMID: 25773654
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The complex structure of tendons relates to their mechanical properties. Previous research has associated the waviness of collagen fibers (crimp) during quasi-static tensile loading to tensile mechanical properties, but less is known about the role of fatigue loading on crimp properties. In this study (IACUC approved), mouse patellar tendons were fatigue loaded while an integrated plane polariscope simultaneously assessed crimp properties. We demonstrate a novel structural mechanism whereby tendon crimp amplitude and frequency are altered with fatigue loading. In particular, fatigue loading increased the crimp amplitude across the tendon width and length, and these structural alterations were shown to be both region and load dependent. The change in crimp amplitude was strongly correlated to mechanical tissue laxity (defined as the ratio of displacement and gauge length relative to the first cycle of fatigue loading assessed at constant load throughout testing), at all loads and regions evaluated. Together, this study highlights the role of fatigue loading on tendon crimp properties as a function of load applied and region evaluated, and offers an additional structural mechanism for mechanical alterations that may lead to ultimate tendon failure.
Metrics
Details
- Title
- Evaluating changes in tendon crimp with fatigue loading as an ex vivo structural assessment of tendon damage
- Creators
- Benjamin R Freedman - University of PennsylvaniaAndrey Zuskov - University of PennsylvaniaJoseph J Sarver - Drexel UniversityMark R Buckley - University of PennsylvaniaLouis J Soslowsky - University of Pennsylvania
- Publication Details
- Journal of orthopaedic research, v 33(6), pp 904-910
- Publisher
- Wiley
- Grant note
- P30 AR050950 / NIAMS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000354024300017
- Scopus ID
- 2-s2.0-84928828200
- Other Identifier
- 991019168725604721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Orthopedics