Journal article
Evaluating fabrication feasibility and biomedical application potential of in situ 3D printing technology
Rapid prototyping journal, v 22(6), pp 947-955
01 Jan 2016
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Purpose - This paper aims to present a solid freeform fabrication-based in situ three-dimensional (3D) printing method. This method enables simultaneous cross-linking alginate at ambient environmental conditions (temperature and pressure) for 3D-laden construct fabrication. The fabrication feasibility and potentials in biomedical applications were evaluated.
Design/methodology/approach - Fabrication feasibility was evaluated as the investigation of fabrication parameters on strut formability (the capability to fabricate a cylindrical strut in the same diameter as dispensing tip) and structural stability (the capability to hold the fabricated 3D-laden construct against mechanical disturbance). Potentials in biomedical application was evaluated as the investigation on structural integrity (the capability to preserve the fabricated 3D-laden construct in cell culture condition).
Findings - Strut formability can be achieved when the flow rate of alginate suspension and nozzle travel speed are set according to the dispensing tip size, and extruded alginate was cross-linked sufficiently. A range of cross-linking-related fabrication parameters was determined for sufficient cross-link. The structural stability and structural integrity were found to be controlled by alginate composition. An optimized setting of the alginate composition and the fabrication parameters was determined for the fabrication of a desired stable scaffold with structural integrity for 14 days.
Originality/value - This paper reports that in situ 3D printing is an efficient method for 3D-laden construct fabrication and its potentials in biomedical application.
Metrics
Details
- Title
- Evaluating fabrication feasibility and biomedical application potential of in situ 3D printing technology
- Creators
- Yigong Liu - Drexel Univ, Dept Mech Engn & Mech, Philadelphia, PA 19104 USAQudus Hamid - Drexel Univ, Dept Mech Engn & Mech, Philadelphia, PA 19104 USAJessica Snyder - MIT, Senseable City Lab, 77 Massachusetts Ave, Cambridge, MA 02139 USAChengyang Wang - Drexel Univ, Dept Mech Engn & Mech, Philadelphia, PA 19104 USAWei Sun - Drexel Univ, Dept Mech Engn & Mech, Philadelphia, PA 19104 USA
- Publication Details
- Rapid prototyping journal, v 22(6), pp 947-955
- Publisher
- Emerald Group Publishing
- Number of pages
- 9
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:000387560000009
- Scopus ID
- 2-s2.0-84992188340
- Other Identifier
- 991019167541204721
UN Sustainable Development Goals (SDGs)
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Engineering, Mechanical
- Materials Science, Multidisciplinary