Files and links (1)
Accepted (AM)Open Access (License Unspecified), Open
Journal article
Evaluating the Properties of a Frailty Index and Its Association With Mortality Risk Among Patients With Systemic Lupus Erythematosus
Arthritis & rheumatology (Hoboken, N.J.), v 71(8), pp 1297-1307
Aug 2019
PMID: 30771242
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To evaluate the properties of a frailty index (FI), constructed using data from the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort, as a novel health measure in systemic lupus erythematosus (SLE).
For this secondary analysis, the baseline visit was defined as the first study visit at which both organ damage (SLICC/American College of Rheumatology Damage Index [SDI]) and health-related quality of life (Short-Form 36 [SF-36] scores) were assessed. The SLICC-FI was constructed using baseline data. The SLICC-FI comprises 48 health deficits, including items related to organ damage, disease activity, comorbidities, and functional status. Content, construct, and criterion validity of the SLICC-FI were assessed. Multivariable Cox regression was used to estimate the association between baseline SLICC-FI values and mortality risk, adjusting for demographic and clinical factors.
In the baseline data set of 1,683 patients with SLE, 89% were female, the mean ± SD age was 35.7 ± 13.4 years, and the mean ± SD disease duration was 18.8 ± 15.7 months. At baseline, the mean ± SD SLICC-FI score was 0.17 ± 0.08 (range 0-0.51). Baseline SLICC-FI values exhibited the expected measurement properties and were weakly correlated with baseline SDI scores (r = 0.26, P < 0.0001). Higher baseline SLICC-FI values (per 0.05 increment) were associated with increased mortality risk (hazard ratio 1.59, 95% confidence interval 1.35-1.87), after adjusting for age, sex, steroid use, ethnicity/region, and baseline SDI scores.
The SLICC-FI demonstrates internal validity as a health measure in SLE and might be used to predict future mortality risk. The SLICC-FI is potentially valuable for quantifying vulnerability among patients with SLE, and adds to existing prognostic scores.
Metrics
Details
- Title
- Evaluating the Properties of a Frailty Index and Its Association With Mortality Risk Among Patients With Systemic Lupus Erythematosus
- Creators
- Alexandra Legge - Dalhousie UniversitySusan Kirkland - Dalhousie UniversityKenneth Rockwood - Dalhousie UniversityPantelis Andreou - Dalhousie UniversitySang-Cheol Bae - Hanyang University Seoul HospitalCaroline Gordon - University of BirminghamJuanita Romero-Diaz - Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránJorge Sanchez-Guerrero - Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránDaniel J Wallace - Cedars-Sinai Medical CenterSasha Bernatsky - McGill UniversityAnn E Clarke - University of CalgaryJoan T Merrill - Oklahoma Medical Research FoundationEllen M Ginzler - SUNY Downstate Health Sciences UniversityPaul Fortin - Université LavalDafna D Gladman - Toronto Western HospitalMurray B Urowitz - Toronto Western HospitalIan N Bruce - Manchester University NHS Foundation TrustDavid A Isenberg - University College LondonAnisur Rahman - University College LondonGraciela S Alarcón - University of Alabama at BirminghamMichelle Petri - Johns Hopkins MedicineMunther A Khamashta - St Thomas' HospitalM A Dooley - University of North Carolina at Chapel HillRosalind Ramsey-Goldman - Northwestern UniversitySusan Manzi - Allegheny Health NetworkKristjan Steinsson - Reykjavík UniversityAsad A Zoma - Hairmyres HospitalCynthia Aranow - Feinstein Institute for Medical ResearchMeggan Mackay - Feinstein Institute for Medical ResearchGuillermo Ruiz-Irastorza - University of the Basque CountryS Sam Lim - Emory UniversityMurat Inanc - Istanbul UniversityRonald F van Vollenhoven - Karolinska InstitutetAndreas Jonsen - Lund UniversityOla Nived - Lund UniversityManuel Ramos-Casals - Hospital Clínic de BarcelonaDiane L Kamen - Medical University of South CarolinaKenneth C Kalunian - University of California, San DiegoSoren Jacobsen - Copenhagen University HospitalChristine A Peschken - University of ManitobaAnca Askanase - New York University Langone Orthopedic HospitalJohn G Hanly - Queen Elizabeth II Health Sciences Centre
- Publication Details
- Arthritis & rheumatology (Hoboken, N.J.), v 71(8), pp 1297-1307
- Publisher
- Wiley
- Grant note
- P30 AR072579 / NIAMS NIH HHS M01 RR000046 / NCRR NIH HHS UL1 TR000150 / NCATS NIH HHS Wellcome Trust UL1 TR001422 / NCATS NIH HHS UL1 RR025741 / NCRR NIH HHS P60 AR048098 / NIAMS NIH HHS P60 AR064464 / NIAMS NIH HHS MOP-88526 / CIHR A3865 / Danish Rheumatism Association
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- General Internal Medicine
- Web of Science ID
- WOS:000477744800013
- Scopus ID
- 2-s2.0-85064459503
- Other Identifier
- 991021933900204721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Rheumatology