Journal article
Evaluating the use of lamotrigine to reduce mood lability and impulsive behaviors in adults with chronic and severe eating disorders
Eating and weight disorders, v 27(5), pp 1775-1785
01 Jun 2022
PMID: 35298791
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background Gold-standard psychological and pharmacological treatments for bulimic-spectrum eating disorders only result in remission for around 50% of patients; patients with affective lability and impulsivity represent a subgroup with particularly poor outcomes. Both dialectical behavior therapy (DBT), a treatment for emotion dysregulation, and lamotrigine, a mood stabilizer, have demonstrated promise for targeting affective lability and impulsivity; however, data exploring the combination of these interventions remain limited. Objective We followed a group of women with recurrent dysregulated eating behaviors (N = 62) throughout intensive DBT treatment and compared the symptom trajectory of those prescribed lamotrigine (n = 28) and those who were not (n = 34). Method Participants completed surveys every 2 weeks throughout treatment. Results Group analyses suggested that all participants self-reported decreases in emotional reactivity, negative urgency, and symptoms of borderline personality disorder (BPD). The lamotrigine group reported greater elevations in BPD symptoms at baseline, but demonstrated steeper decreases in emotion and behavioral dysregulation than the non-matched comparison group. Within-subject analyses suggested that within the lamotrigine group, subjects reported greater decreases in symptoms following prescription of lamotrigine. Conclusions Findings provide initial data suggesting that lamotrigine could be useful as an adjunctive treatment for patients with affective lability and impulsivity.
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Details
- Title
- Evaluating the use of lamotrigine to reduce mood lability and impulsive behaviors in adults with chronic and severe eating disorders
- Creators
- Erin E. Reilly - University of California, San FranciscoLaura A. Berner - Icahn School of Medicine at Mount SinaiMary Ellen Trunko - University of California San DiegoTerry Schwartz - University of California San DiegoLeslie K. Anderson - University of California San DiegoAngeline Krueger - University of California San DiegoXinze Yu - University of California San DiegoJoanna Y. Chen - Drexel UniversityAnne Cusack - University of California San DiegoTiffany Nakamura - University of California San DiegoWalter H. Kaye - University of California San Diego
- Publication Details
- Eating and weight disorders, v 27(5), pp 1775-1785
- Publisher
- Springer Nature
- Number of pages
- 11
- Grant note
- F32MH108311; K23MH118418 / National Institutes of Mental Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) Hilda and Preston Davis Foundation
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000770195900001
- Scopus ID
- 2-s2.0-85126371225
- Other Identifier
- 991019319077404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Psychiatry