Journal article
Evaluation and recommendations for therapy of advanced mycosis fungoides lymphoma
International journal of radiation oncology, biology, physics, v 5(1), pp 23-27
1979
PMID: 106034
Abstract
Between 1 January 1975 and 1 October 1977, 30 patients with biopsy proven mycosis fungoides lymphoma were treated to the total skin surface utilizing 3.8 MeV. Only
8
30
(2786) had “early” disease and
22
30
(739) had “late” disease. All but 4 patients had been unresponsive to previous topical therapy or were unable to tolerate continued topical therapy because of skin sensitivity. Of 28 patients eligible for examination, 16 (57%) either failed to demonstrate complete disease clearance or, if initial clearance occurred, they had recurrent disease within 3 months. An additional 3 patients recurred within 4–6 months. Results suggest that electron beam irradiation alone is unable to induce and maintain clearance of disease in patients with advanced involvement or in those who have failed on previous topical therapy. Treatment failure may be related to development of a relatively resistant cell line (
26
30
patients had failed on previous therapy) or to the therapeutic and prognostic implications of cutaneous tumors or extra-cutaneous disease.
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Details
- Title
- Evaluation and recommendations for therapy of advanced mycosis fungoides lymphoma
- Creators
- Paul E. Wallner - Hahnemann University HospitalEric C. Vonderheid - Skin Cancer FoundationLuther W. Brady - Hahnemann University HospitalEugene J. Van Scott - Skin Cancer FoundationSucha O. Asbell - Einstein Medical Center Philadelphia
- Publication Details
- International journal of radiation oncology, biology, physics, v 5(1), pp 23-27
- Publisher
- Elsevier
- Number of pages
- 5
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:A1979GH71000003
- Scopus ID
- 2-s2.0-0018741345
- Other Identifier
- 991021901008104721