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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Evaluation of 4 Presurgical Skin Preparation Methods in Mice
Journal of the American Association for Laboratory Animal Science, v 58(1), pp 71-77
01 Jan 2019
PMID: 30609948
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Mice routinely undergo surgical procedures for use in research; however, studies of skin preparation methods to achieve antisepsis are rare. The present study evaluated 4 skin preparation treatments: depilatory agent followed by povidone-iodine and alcohol scrub; depilatory agent followed by povidone-iodine and saline scrub; electric clippers followed by povidone-iodine and alcohol scrub; and electric clippers followed by povidone-iodine and saline scrub. Swabs for bacterial culture were obtained immediately after hair removal and after scrubbing to measure the reduction in bacterial load. Full-thickness incisions were assigned ASEPSIS wound scores and examined histologically on days 0, 1, and 7 after surgery. Neither bacterial load growth nor ASEPSIS wound scores differed among any of the treatments. Histopathology revealed statistically significant but biologically irrelevant differences. Overall all treatment methods achieved acceptable bacterial load reduction and surgical site healing.
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Details
- Title
- Evaluation of 4 Presurgical Skin Preparation Methods in Mice
- Creators
- Brenda L Kick - Emory UniversitySanjeev Gumber - Emory UniversityHeqiong Wang - Emory UniversityReneé H Moore - Emory UniversityDouglas K Taylor - Emory University
- Publication Details
- Journal of the American Association for Laboratory Animal Science, v 58(1), pp 71-77
- Grant note
- P51 OD011132 / NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000463957000009
- Scopus ID
- 2-s2.0-85060403413
- Other Identifier
- 991021448063404721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Veterinary Sciences
- Zoology