Journal article
Evaluation of Early Weight Loss Thresholds for Identifying Nonresponders to an Intensive Lifestyle Intervention
Obesity (Silver Spring, Md.), v 22(7), pp 1608-1616
01 Jul 2014
PMID: 24771618
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective: Weight losses in lifestyle interventions are variable, yet prediction of long-term success is difficult. The utility of using various weight loss thresholds in the first 2 months of treatment for predicting 1-year outcomes was examined.
Methods: Participants included 2327 adults with type 2 diabetes (BMI:35.8 +/- 6.0) randomized to the intensive lifestyle intervention (ILI) of the Look AHEAD trial. ILI included weekly behavioral sessions designed to increase physical activity and reduce caloric intake. 1-month, 2-month, and 1-year weight changes were calculated.
Results: Participants failing to achieve a >= 2% weight loss at Month 1 were 5.6 (95% CI:4.5, 7.0) times more likely to also not achieve a >= 10% weight loss at Year 1, compared to those losing >= 2% initially. These odds were increased to 11.6 (95% CI:8.6, 15.6) when using a 3% weight loss threshold at Month 2. Only 15.2% and 8.2% of individuals failing to achieve the >= 2% and >= 3% thresholds at Months 1 and 2, respectively, go on to achieve a >= 10% weight loss at Year 1.
Conclusions: Given the association between initial and 1-year weight loss, the first few months of treatment may be an opportune time to identify those who are unsuccessful and utilize rescue efforts.
Metrics
Details
- Title
- Evaluation of Early Weight Loss Thresholds for Identifying Nonresponders to an Intensive Lifestyle Intervention
- Creators
- Jessica L. Unick - Miriam HospitalPatricia E. Hogan - Wake Forest UniversityRebecca H. Neiberg - Wake Forest UniversityLawrence J. Cheskin - Bloomberg (United States)Gareth R. Dutton - University of Alabama at BirminghamGina Evans-Hudnall - Baylor College of MedicineRobert Jeffery - University of MinnesotaAbbas E. Kitabchi - University of Tennessee Health Science CenterJulie A. Nelson - American Indian CenterF. Xavier Pi-Sunyer - St. Luke's-Roosevelt Hospital CenterDelia Smith West - University of Arkansas for Medical SciencesRena R. Wing - Miriam HospitalLook AHEAD Res GrpEllen Stephanie Krauthamer Ewing - Drexel University
- Publication Details
- Obesity (Silver Spring, Md.), v 22(7), pp 1608-1616
- Publisher
- Wiley
- Number of pages
- 9
- Grant note
- Centers for Disease Control and Prevention; United States Department of Health & Human Services; Centers for Disease Control & Prevention - USA National Center on Minority Health and Health Disparities; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Minority Health & Health Disparities (NIMHD) Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) National Heart, Lung, and Blood Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) U01DK057154 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) M01RR01066 / Massachusetts General Hospital Mallinckrodt General Clinical Research Center; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) M01RR01346 / Frederic C. Bartter General Clinical Research Center; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) DK57136; DK57149; DK56990; DK57177; DK57171; DK57151; DK57182; DK57131; DK57002; DK57078; DK57154; DK57178; DK57219; DK57008; DK57135; DK56992 / Department of Health and Human Services through the following cooperative agreements from the National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA M01RR02719 / Johns Hopkins Medical Institutions Bayview General Clinical Research Center; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) M01RR000056 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) DK 046204 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA NIH Office of Research on Women's Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Office of Research on Women's Health (ORWH) National Institute of Nursing Research; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Nursing Research (NINR) VA Puget Sound Health Care System Medical Research Service, Department of Veterans Affairs M01RR00051 / University of Colorado Health Sciences Center General Clinical Research Center; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) M01RR0021140 / University of Tennessee at Memphis General Clinical Research Center; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) P30 DK48520 / Clinical Nutrition Research Unit National Institute of Diabetes and Digestive and Kidney Diseases; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) M01RR000056 44 / University of Pittsburgh General Clinical Research Center; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) UL1TR001120 / NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) P20MD006899 / National Institute on Minority Health and Health Disparities; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Minority Health & Health Disparities (NIMHD)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Counseling and Family Therapy; Drexel University
- Web of Science ID
- WOS:000338035400007
- Scopus ID
- 2-s2.0-84903535445
- Other Identifier
- 991020099057104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Endocrinology & Metabolism
- Nutrition & Dietetics