Journal article
Evaluation of Five Novel Intervention Components in Online Obesity Treatment: Outcomes of a Randomized Factorial Experiment
Obesity (Silver Spring, Md.), v 33(11), pp 2128-2138
Nov 2025
PMID: 40968617
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective: This study aimed to optimize weight loss outcomes in an online behavioral obesity treatment program by evaluating the effects of five novel intervention components using a factorial experiment informed by the multiphase optimization strategy framework. Methods: A randomized factorial experiment tested 12-month weight loss resulting from an established online obesity treatment program with randomization to zero to five novel intervention components (interactive video feedback, tailored intervention to promote physical activity, skills for dysregulated eating, virtual reality skills training, and social support with friendly competition). Results: Adults (N = 384; 83% female, 12% male, 5% another sex/gender or did not disclose; 23% racial and/or ethnic minority) with (mean +/- SD) age of 53.5 +/- 11.7 years and BMI of 35.0 +/- 6.1 kg/m(2) were randomized. No intervention component independently improved weight loss (p values > 0.199). Interaction terms (p values < 0.01) suggest the combination of interactive video feedback, skills for dysregulated eating, and social support with friendly competition improved weight loss. Mediation analysis indicated that social support and dysregulated eating interventions influenced weight loss outcomes through improvements in social support for physical activity and dietary quality. Conclusions: This study identified a combination of intervention components that may improve weight loss outcomes compared to the established online treatment program.
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Details
- Title
- Evaluation of Five Novel Intervention Components in Online Obesity Treatment: Outcomes of a Randomized Factorial Experiment
- Creators
- J. Graham Thomas - Miriam HospitalCarly M. Goldstein - Miriam HospitalDale S. Bond - Brown UniversityJason Lillis - Brown UniversityEric Hekler - Human LongevityStephanie P. Goldstein - Miriam Hosp, Weight Control & Diabet Res Ctr, Providence, RI 02906 USAMeghan L. Butryn - Drexel University, Psychological and Brain Sciences (Psychology)Zihuan Cao - MiriamRena R. Wing - Brown University
- Publication Details
- Obesity (Silver Spring, Md.), v 33(11), pp 2128-2138
- Publisher
- Wiley
- Number of pages
- 11
- Grant note
- R01 DK117857 / National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology); WELL Center
- Web of Science ID
- WOS:001575399700001
- Scopus ID
- 2-s2.0-105016488847
- Other Identifier
- 991022098423604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Endocrinology & Metabolism
- Nutrition & Dietetics